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Transdermal Formulation Crystal Structure Analysis

Inquiry

Crystal form refers to the structural form and arrangement of crystals. In drug research and formulation development, the crystal form has an important impact on the stability, bioavailability, solubility, and formulation performance of the active ingredient of the drug. CD Formulation can provide you with professional transdermal formulation crystal structure analysis.

About Transdermal Formulation Crystal Structure Analysis

Crystal structure analysis of transdermal patches can provide information about the drug's crystal morphology, crystal structure, lattice constants, etc., and help us understand the release performance and dissolution kinetics of the drug in the patch. The crystal structure of the drug in the patch may change due to environmental factors, such as humidity, temperature, light, etc. Through crystal structure analysis, the stability of drug crystals in patches can be evaluated and the formula and preparation process of patches can be optimized.

What Can We Offer

Improve the bioavailability and efficacy of drugs

Drugs of different crystal forms have different molecular structures, and their solubility, stability, affinity and other biological activities will also be different. By studying the differences between different crystal forms, we can optimize the structure and performance of drugs for you, thereby improving their bioavailability and efficacy.

Reduce the toxicity and side effects of drugs

Some drugs may have large toxicity differences between different crystal forms. By deeply studying the toxicity differences of different crystal forms, we can optimize the structure and performance of drugs for you, reduce their toxicity and side effects, and improve the safety of medication.

Our Workflow of Transdermal Formulation Crystal Structure Analysi s

Our steps for transdermal formulation crystal structure analysis are as follows:

Workflow of crystal structure analysis of transdermal patches. Fig.1 Flow chart of transdermal formulation crystal structure analysis (CD Formulation)

Our Technology Platform

We usually use the following experimental techniques to analyze the crystal structure of the patch:

Technology	Description
X-ray diffraction (XRD)	By measuring the diffraction angle and intensity of X-rays by a sample, the unit cell parameters, crystal system, space group and other information of the crystal can be determined.
Single crystal X-ray diffraction	The precise position, bond length, bond angle, etc. of each atom in the crystal can be determined.
Raman spectroscopy	High-resolution point scanning can accurately locate the location of active ingredients and quickly and accurately identify crystal forms.

Why Choose Us for Analyzing Transdermal Formulation Crystal Structure?

We use professional equipment and technology for crystal structure analysis to ensure the accuracy and reliability of analysis results.
Our technical staff have extensive experience and expertise in crystal structure analysis. Understand the advantages and disadvantages of various analysis methods, be able to select the most appropriate analysis technology based on the characteristics of the sample, and provide effective solutions to specific problems.
We are equipped with advanced experimental equipment and professional technical personnel, capable of efficiently conducting crystal structure analysis. They are able to complete the analysis in a short period of time and provide high-quality analysis reports to meet customer needs.

Published Data

Technology: Methods to transdermal formulation crystal structure analysis

Journal: International Journal of Drug Delivery

IF: 1.529

Published: 2012

Results: The present study is about development and validation of a quantitative X-ray diffraction method for the determination of the extent of crystallization of the drug in transdermal formulation of Granisetron. Specimens of different physically spiked concentrations were carefully prepared accurately by weighing and distributing crystalline active pharmaceutical ingredient (API) onto placebo liner patches, pasted on Silicon low background sample holder (diameter of 24.5 mm, made up of Si crystal). All the specimens thus prepared were scanned using optimized instrumental parameters while enabling specimen rotation during the diffraction analysis to ensure homogeneous exposure to the incident X-rays.

Crystallization of transdermal patches. Fig.2 An illustration demonstrating crystallization in transdermal patches (Dr. Pavan Kommavarapu, et al., 2012)

Through crystal structure analysis, the stability of drug crystals in patches can be evaluated and the formula and preparation process of patches can be optimized. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

Dr. Pavan Kommavarapu, Arthanareeswari Maruthapillai, et al. An approach to determine crystalline content of Granisetron in transdermal patches using X-ray diffraction technique. International Journal of Drug Delivery. (2012) 4(4):492-497.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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