Transdermal Formulation Adhesion Testing

In the field of pharmaceutical research and development and innovation, transdermal formulations are gradually becoming the focus of market attention because of their unique delivery methods and excellent therapeutic effects. To ensure the safety and effectiveness of transdermal formulations, adhesion is one of the core indexes. CD Formulation specializes in adhesion testing for transdermal formulations and is dedicated to offering researchers comprehensive, accurate, and efficient testing services.

About Transdermal Formulation Adhesion Testing

The adhesion of transdermal formulations is the guarantee of continuous supply of their efficacy. The patch must remain in full contact with the skin throughout the delivery process to ensure that it does not migrate or fall off during use, thus facilitating the absorption of the drug in the patch into the systemic circulation through the skin. If the adhesion ability is too strong, when the administration is stopped or the skin needs to be peeled off at the end of the administration, it may cause adverse reactions such as skin residual glue or skin damage, affecting the overall usability of the product.

Our Transdermal Formulation Adhesion Testing Services

We conduct several types of adhesion tests to evaluate various aspects of transdermal patch performance:

Testing Types

• Peel Test: Measures the force required to peel the patch off the skin.
• Shear Test: Assesses the resistance of the adhesive to shearing forces, which can occur when the skin or patch is subjected to friction.
• Tack Test: Evaluates the initial stickiness or tackiness of the adhesive.
• Peel Adhesion Test: Similar to the peel test, but often conducted under standardized conditions to compare different adhesives.
• Removal Test: Assesses how easily the patch can be removed from the skin without leaving residue or causing skin damage.

Testing Methods

• Peel Test: A patch is applied to a substrate, and then a peel force is applied to separate the patch. The force is measured using a peel tester.
• Shear Test: A patch is applied to a substrate, and a shear force is applied parallel to the surface. The amount of force required to slide the patch is recorded.
• Tack Test: A probe or tack meter is used to measure the force needed to separate the adhesive from the surface immediately after application.
• Peel Adhesion Test: The patch is peeled off at a specific angle and speed, and the adhesion strength is measured.
• Removal Test: The patch is removed under controlled conditions, and any residue or damage is evaluated.

Fig.1 Transdermal formulation adhesion testing. (Eva Gutschke, et al. 2010)

Our Workflow

1. Preparation

Choose the transdermal patches and any substrates or test surfaces. Place the transdermal patch on the surface with the adhesive side down. Press it down uniformly to ensure good contact and adhesion.

2. Adhesion Testing

Peel Test: Use a peel tester to apply a steady force to peel the patch away from the substrate at a specific angle (usually 180 degrees) and speed.

Shear Test: Apply a shear force parallel to the surface. This can be done using a shear tester or similar device.

Tack Test: Use a tack meter to press a probe into the adhesive and then pull it away.

3. Removal Testing

Remove the patch from the surface at a controlled speed.

4. Data Analysis

Compare the measured adhesion values against the specifications and standards for the formulation.

Fig.2 Flow chart of adhesion testing (CD Formulation)

Why Choose Us for Transdermal Formulation Adhesion Testing?

• Expertise and Experience: Our team consists of highly skilled professionals with extensive experience in adhesion testing for transdermal formulations. Their deep understanding of both the science behind transdermal systems and the specific challenges related to adhesion ensures accurate and reliable testing outcomes.
• State-of-the-Art Adhesion Testing Instruments: Our company is equipped with the latest, high-precision instruments designed specifically for adhesion testing of transdermal patches. This advanced equipment enables accurate measurement of adhesive strength, peel, tack, and shear properties.
• Problem-Solving Capabilities: With a strong background in transdermal delivery systems, our team can quickly identify and address any adhesion-related issues that arise during testing. Their problem-solving skills are crucial in optimizing formulations to meet performance and regulatory requirements.

Published Data

CD Formulation is at the cutting edge of adhesion testing for transdermal formulations, thanks to the combination of our highly skilled technical staff and advanced equipment. This unique advantage guarantees that your transdermal patches will be effective and adhere to high-quality standards. For any of your research and development needs, please do not hesitate to contact us, and our team will respond within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.