A hydrogel is a three-dimensional polymer network whose core can hold a large amount of water while not dissolving. The hydrogel network promotes binding to other macromolecules, thereby forming a cage-like structure in the form of a matrix. Smart hydrogels have the same properties as traditional hydrogels with the addition of stimuli-sensitive behavior, which makes them a more promising type of hydrogel for biomedical applications. Smart hydrogels respond to a variety of stimuli, including temperature, pressure, pH, biosignals, light, and enzyme reactions. CD Formulation has professional knowledge and technology accumulation in the field of gel transdermal formulations and provides you with formulation development services for various organized transdermal formulations.

What is Thermosensitive Gel Transdermal Formulation?

Thermosensitive gels are temperature-responsive in-situ gels that transform from a liquid state at room temperature to a semi-solid state at body temperature, providing enhanced adhesion and stability at the administration site. This sol-gel transition allows for controlled drug release and the maintenance of drug activity. Thermosensitive gels are highly compatible with tissues and bypass physiological barriers, making them a key area of focus in pharmaceutical and biotechnological applications.

Fig.1 Illustration of thermosensitive hydrogel-based medical dressing. (A) illustration of the synthesis of the silk fabric-based CGG hydrogel medical dressing. (B) Illustration of the medical dressing containing silk fabric penetrated with CGG hydrogel. (C) Transdermal application of thermos-responsive medical dressing for analgesic and antipyretic conditions. (Bangul Khan, et al. 2023)

What Can We Offer?

Thermosensitive Gel Material Synthesis

We specialize in synthesizing temperature-sensitive biomaterials, including synthetic materials like poloxamers, poly N-isopropyl acrylamide, and polyethylene glycol-polyesters, as well as natural polymers like chitosan and cellulose. These materials utilize hydrogen bonds, π-π interactions, Van der Waals forces, and hydrophobic interactions to create robust gels.

Development of Composite Formulations

For complex drug delivery needs, we develop composite formulations by combining thermosensitive gels with microspheres, liposomes, nanoparticles, and inclusion compounds. This enhances performance and optimizes sustained and controlled drug release.

Thermosensitive Gel Patch Development for Different Administration Sites

We develop customized thermosensitive gel patches for a variety of administration sites, tailored to meet your specific clinical requirements.

Fig.2. Thermosensitive gel patch formulation development service for different administration sites. (CD Formulation)

In vitro Cytotoxicity Testing

• Epidermal culture
• Lactate dehydrogenase (LDH) assay (Cell membrane integrity test)
• MTT assay (Cell viability test)

Our Development Process of Thermosensitive Gel Transdermal Formulations

• Consultation and Requirement Assessment: We begin by thoroughly discussing your project goals and transdermal formulation needs.
• Formulation Design: Our team designs the most appropriate thermosensitive gel formulation based on your clinical requirements.
• Material Synthesis and Optimization: We synthesize and optimize thermosensitive gel materials, focusing on controlled release performance.
• In Vitro and Ex Vivo Testing: We conduct comprehensive in vitro cytotoxicity testing and ex vivo studies to evaluate the safety and efficacy of the gel.
• Delivery and Feedback: Once the formulation is finalized, we deliver the product and provide ongoing support based on your feedback.

Our Characterization Platform

Our Advantages in Thermosensitive Gel Transdermal Formulation Development

• Expertise in Transdermal Drug Delivery Systems (TDDS): With extensive R&D experience, we understand the mechanisms behind transdermal absorption and factors influencing drug efficacy, allowing us to design scientifically advanced formulations.
• Material Science Prowess: Our deep expertise in materials science allows us to select and optimize polymers, enhancing the gel's controlled release and transdermal efficiency.
• Preclinical Research Capabilities: We offer comprehensive preclinical testing, including pharmacodynamics, pharmacokinetics, and safety evaluation, ensuring the effectiveness and safety of the formulations.

Published Data

We have the ability to develop and optimize thermosensitive materials such as Poloxam, polyethylene glycol, etc., which undergo phase transitions in response to changes in ambient temperature to form a stable gel layer at body temperature, providing a continuous release platform for drugs. With advanced R&D technology, CD Formulation is committed to bringing you more efficient and safer gel products. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.