Hydrogels are three-dimensional network polymers that absorb water, retaining a significant amount while remaining insoluble. These can be classified as traditional or smart (sensitive) hydrogels. Traditional hydrogels show little response to environmental changes, while sensitive hydrogels react to stimuli like temperature, pH, light, or magnetic fields. Sensitive hydrogels, also called smart hydrogels, undergo rapid structural and chemical changes in response to such stimuli. At CD Formulation, we specialize in gel-based transdermal formulations, offering comprehensive services for the development of pH-sensitive gels designed for optimized transdermal drug delivery.

What is pH-sensitive Gel Transdermal Formulation?

A pH-sensitive gel's functionality is driven by its ability to swell or shrink depending on environmental pH. This change results from the ionization of acid or base groups within the gel's polymer network. In transdermal drug delivery systems, the natural pH differences between the skin and bloodstream can be leveraged to trigger targeted drug release.

Fig.1 (a) pH-dependent ionization of specific acidic or basic functional groups on hydrogel chains responsible for swelling, (b) pH-dependent swelling and drug release mechanism. (Muhammad Rizwan, et al. 2017)

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Gel Matrix Screening

We select the most suitable gel matrix based on the drug's characteristics to optimize transdermal administration.

Polymer Concentration Design

By adjusting polymer concentrations, we control the gel's swelling properties and regulate drug release rates.

Drug Loading Design

We tailor drug loading based on its properties and therapeutic needs to ensure effective release and absorption.

pH Adjuster Design

The addition of pH adjusters optimizes initial gel pH for enhanced drug release.

pH-sensitive Polymers We Provide

Our Workflow for pH-Sensitive Gel Transdermal Formulation Development

Fig.2 Flow chart of pH-sensitive Gel Transdermal Formulation Development. (CD Formulation)

Material selection and optimization

• Choose pH-sensitive polymers and suitable drugs for transdermal delivery.
• Include necessary excipients (e.g., penetration enhancers, preservatives) for improved performance and stability.

Preparation and optimization

• Develop the gel formulation through precise dissolution, mixing, and molding processes.
• Test pH sensitivity and adjust formulation and processing parameters to optimize drug release and gel performance.

Performance evaluation and verification

• Conduct transdermal absorption studies using animal models or artificial skin to assess and verify the gel's absorption rate and efficacy.

Our Analytical Capabilities

Why Choose CD Formulation?

• Our team of experts includes medicinal chemists, material scientists, and skin physiologists with extensive experience in pH-sensitive gel formulation.
• We utilize advanced facilities and instruments, enabling precise control over pH sensitivity and drug delivery performance.
• Customized transdermal formulations are developed for specific diseases and therapeutic needs, with optimized drug loading and release profiles.

Published Data

By optimizing formulation processes, including crosslinking density and drug embedding techniques, we can further enhance the stability and therapeutic performance of pH-sensitive gel formulations. We offer tailored development services to meet the specific needs of our clients. contact us for more information and expect a response within three business days.