Gels are viscoelastic polymers composed of colloidal particles or interconnected polymer chains forming a three-dimensional network within a liquid. Due to their comfortable texture, air permeability, and compatibility, gels are ideal for transdermal drug delivery. CD Formulation offers comprehensive development services for organogel-based transdermal systems that mitigate gastrointestinal irritation and expand the applicability of various drugs.

What is Organogel Transdermal Formulation?

Organogels are gel-based systems formed with non-polar solvents like hexane, isopropyl myristate, or natural oils such as sunflower or corn oil. These formulations are gaining popularity due to their simple preparation and stable structures, accommodating both hydrophilic and hydrophobic compounds. Organogels enable controlled drug release through multiple administration routes and are thermoreversible, making them versatile for drug delivery applications.

Fig.1. Schematic representation of drug delivery strategies. (Sushil Raut, et al. 2024)

Key Benefits of Organogel Transdermal Formulations

• Easy Preparation: Organogels have straightforward manufacturing processes.
• Microbial Resistance: Their organic composition provides natural resistance to contamination.
• Cost-Efficient: Fewer ingredients lead to reduced production costs.
• Drug Compatibility: They can encapsulate both hydrophilic and hydrophobic drugs.
• Stable and Safe: Organogels are thermodynamically stable, non-toxic, and non-irritating.

Organogel Types We Can Develop

Lecithin Organogels (LOs)

Lecithin organogels are biocompatible systems that enhance drug solubility and permeability, making them ideal for transdermal delivery. These isotropic gels consist of phospholipids and are known for their stability and ease of application.

Pluronic Lecithin Organogels (PLOs)

These organogels are formulated using soy lecithin, isopropyl myristate, water, and Pluronic F127. They serve as efficient carriers for hydrophobic and hydrophilic molecules in topical and transdermal treatments.

Premium Lecithin Organogels (PrLOs)

PrLOs offer enhanced thermal stability, non-greasy textures, and are free from Pluronic derivatives, reducing skin irritation and ensuring better aesthetic acceptability.

Gelatin-Stabilized Microemulsion-Based Organogels (MBG)

Formed by cooling concentrated gelatin solutions, MBGs are used for the controlled release of hydrophobic drugs in topical or transdermal applications.

Fatty-Acid-Derived Sorbitan Organogels

Containing sorbitan monostearate or monopalmitate as gelling agents, these organogels are hydrophobic, non-ionic, and effective in immobilizing a range of solvents.

Figure 2. Schematic illustration of network arrangements of different types of organogels. (a) Fluid filled matrix: pluronic lecithin organogel and lecithin organogel. (b) Solid fiber matrix: limonene, sorbitan, eudragit, and microemulsion-gelatin-based organogel. (c) Chemical organogel: supramolecular organogel. (Sushil Raut, et al. 2024)

Our Development Process of Organogel Transdermal Formulations

At CD Formulation, we follow a meticulous process to develop customized organogel transdermal formulations:

Initial Consultation: We gather detailed client requirements and conduct feasibility assessments.

Formulation Design: Our team selects appropriate solvents, gelling agents, and active ingredients based on the target drug properties.

Prototyping: We create prototypes and optimize the gel matrix to enhance drug absorption and skin penetration.

Testing & Optimization: We conduct thorough in vitro release and penetration studies, adjusting the formulation for maximum efficacy.

Our Analytical Capabilities

Our Advantages in Organogel Transdermal Formulation Development

• Advanced Formulation Techniques: We utilize innovative processes like coating and spray drying to create uniform, effective gels.
• Cutting-Edge Technologies: We incorporate microneedle and iontophoresis technologies to enhance drug delivery through the skin.
• State-of-the-Art Equipment: Our laboratory is equipped with viscometers and advanced optical microscopes for precise formulation analysis and testing.

Published Data

By adjusting the formulation and composition of the organogels, we successfully improved the efficiency of transdermal drug delivery. For example, choosing the right gel matrix and adding transdermal accelerators can effectively enhance the skin permeability of the drug. With advanced R&D technology, CD Formulation is committed to bringing you more efficient and safer gel products. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.