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Nanostructures Visualization Analysis of Nano Transdermal Formulation

Inquiry

The visualization analysis of the nanostructure of nano transdermal formulations is an important research method, which can help us to have a deeper understanding of the transdermal absorption mechanism of nano transdermal formulations and the distribution of drugs in the skin. CD Formulation can provide you with professional nanostructure visualization analysis of nano transdermal formulation.

About Nanostructure Visualization Analysis of Nano Transdermal Formulations

Nanotransdermal formulations refer to drug delivery systems prepared using nanotechnology that can enhance the transdermal absorption of drugs. Such preparations usually have nanoscale sizes and can penetrate the skin barrier to deliver drugs to the subcutaneous tissue or blood, thereby achieving therapeutic effects. We combine knowledge from multiple disciplines such as chemistry, physics, biology, and materials science, and use visualization analysis of nanostructures to help you understand the structure-property relationship of nanotransdermal formulations to ensure their efficacy, safety, and stability.

What Can We Offer

We can provide you with in-depth insights into the structure of nanocarriers or nanoparticles used in formulations.
We can help you understand the internal organization and integrity of nanoformulations.
We can provide you with information on the hydrodynamic diameter and polydispersity of nanoparticles in transdermal formulations.
We can help you determine the crystallinity, crystal structure, and phase composition of nanoparticles or carrier materials in transdermal formulations.
We can characterize the chemical composition, and the interaction between nanoparticles and excipients and monitor structural changes caused by the formulation process.

Our Process for Visualizing Nanostructures in Transdermal Formulation Analysis

Fig.1 Workflow of nanostructure visualization analysis of nano transdermal formulations. Fig.1 Flow chart of nanostructures visualization analysis of nano transdermal formulations. (CD Formulation)

1. Sample preparation

Prepare the corresponding samples according to the characteristics of nano transdermal formulations and the purpose of analysis.

2. Select visualization technology

Select the appropriate visualization technology for nano transdermal formulations.

3. Set visualization parameters

Set the corresponding parameters according to the characteristics of the selected visualization technology.

4. Perform visualization analysis

Observe and analyze the formulations using the selected visualization technology. Record and analyze information such as the morphology, size, distribution, and dynamic process of nanoparticles.

5. Data processing

Interpret the characteristics of nanostructures in combination with the preparation method and application purpose of nano transdermal formulations.

Our Technology Platform

Technologies	Description
X-ray Diffraction (XRD)	Used to determine the crystallinity, crystal structure, and phase composition of nanoparticles or carrier materials in transdermal formulations.
Transmission Electron Microscopy (TEM)	Ideal for detailed examination of internal nanostructures such as core-shell structure, crystallinity, and particle morphology. It helps understand the internal organization and integrity of nanoformulations.
Scanning Electron Microscopy (SEM)	Used to visualize surface morphology, particle size, shape, and distribution in transdermal formulations. It provides insight into the structure of nanocarriers or nanoparticles used in formulations.

Why Choose Us for Nanostructure Visualization Analysis?

Our instruments have high-resolution imaging features, which enable precise observation and analysis of nanostructures in nano-transdermal preparations.
We can not only observe the morphology and distribution of nanostructures but also combine other characterization techniques to obtain information on the physical, chemical, and biological properties of nano-transdermal preparations.
Our tests are fast and accurate, allowing faster experimental results and accelerated research progress.

Published Data

Technology: Methods to nanostructures visualization analysis

Journal: Nanoscale Advances

IF: 4.7

Published: 2023

Results: Fluorescence spectroscopy can be used to track skin penetration in vivo by exciting fluorophores connected to the nanocarrier (normally in the UV to near IR spectral range). Endogenous fluorophores (porphyrins, nicotinamide adenine dinucleotide (NADH), collagen, and elastin), fluoresce pharmaceuticals, and exogenous fluorophores are examples of these fluorophores. For example, the transport capacity of zinc(ii) phthalocyanine (ZnPc)-loaded small NPs in the skin has been investigated using fluorescence spectroscopy. The distribution of ZnPc-NPs/(2-hydroxypropyl)-β-cyclodextrin (HPβCD) in different skin layers can be observed. Besides using fluorescence intensity or the emission wavelength as a readout, fluorescence lifetime and time-resolved anisotropy can be employed. Fluorescence lifetime is highly sensitive to the environment and therefore allows, among others, sensing of polarity, pH, calcium concentration, or biomolecular interaction. The analysis of time-resolved anisotropy provides insights into the molecular dynamics of the nanocarrier.

Fig.2 The skin biological structure. Fig.2 Preparation and evaluation of polymer NPs through the skin. (A) Poly (ethylene glycol)-poly (3-caprolactone)-amphiphilic diblock copolymer (PEG-b-PCL) NPs coupled with (2-hydroxypropyl)-b-cyclodextrin (HPbCD) NPs as a novel vehicle for the transdermal delivery of highly lipophilic compounds. (B) The evaluation and characterization of NPs. (i) TEM image of ZnPc-NPs (0.2% theoretical loading) and (ii) colloidal properties of freeze dried ZnPc-NPs/HPbCD stored in the dark at 4 °C after dispersion in water. (C) Fluorescence images of ski sections after 24 h of permeation experiment. ZnPc red fluorescence can be observed. Merged pictures were obtained by superimposing brightfield and fluorescence images of the same area. Scale bar: 500 mm. (Lijun Liu, et al. 2023)

CD Formulation provides you with professional nanostructure visualization analysis of nano transdermal formulations. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

Lijun Liu, Wenbin Zhao, et al. Functional nano-systems for transdermal drug delivery and skin therapy. Nanoscale Advances, 2023, 5, 1527–1558.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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