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Nano Transdermal Formulation Zeta Potential Testing

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Zeta potential is an important characterization parameter of nanomaterials, which can characterize the stability and quality of the dispersed system. CD Formulation has extensive experience in testing nanoformulations and can assist in optimizing the process, quickly assessing product reliability, and speeding up product development.

About Nano Transdermal Formulation Zeta Potential Testing

Zeta potential is a key parameter for evaluating the stability of nanoparticle dispersion systems. A Zeta potential with a high absolute value, for example exceeding ±30mV, indicates a significant charge repulsion among particles. This helps in keeping the system stable and prevents clumping or settling. When conducting a Zeta potential test, factors such as sample concentration, pH value, and ion concentration may affect the test results, so the consistency of the test system and the actual system should be ensured.

What Can We Offer

The main methods for measuring Zeta potential include electrophoresis, electroosmosis, streaming potential, and ultrasonic electroacoustic methods. Electrophoresis and electroosmosis are commonly employed for determining the zeta potential of nanoparticles while streaming potential or ultrasonic electroacoustic techniques are more appropriate for particles exceeding 10 μm in size.

CD Formulation's Zeta potential meter uses the principle of laser Doppler electrophoresis to detect the migration rate of the sample under the applied electric field by analyzing the phase light scattering method and then converts the measured electrophoretic mobility into Zeta potential values and Zeta potential distribution diagrams according to the Henry equation. By monitoring the changes in Zeta potential, we can help you optimize the formulation of the preparation and improve the stability and performance of the preparation.

Our Processing for Zeta Potential Testing of Nano Transdermal Formulations

Fig.1 Workflow of nano transdermal formulation zeta potential testing. Fig.1 Flow chart of nano transdermal formulation zeta potential testing. (CD Formulation)

1. Sample Preparation

Dilution: Prepare diluted samples of nanoformulations in a suitable solvent or buffer that simulates physiological conditions. Homogenization: Ensure that the sample is well mixed to prevent aggregation.

2. Instrument Setup

Calibrate the instrument. Measure the electrophoretic mobility of the particles using a Zeta potential analyzer.

3. Measurement Procedure

Loading: Load the prepared sample into the measurement cell of the Zeta potential analyzer.

Temperature Control: Maintain a stable temperature throughout the measurement to prevent variations.

Measurement: Perform multiple measurements to ensure accuracy and reproducibility.

4. Data Analysis

Zeta Potential Calculation: Zeta potential is calculated based on the electrophoretic mobility of the nanoparticles.

Our Technology Platform

Technologies	Description
Electrophoretic light scattering method	By measuring the electrophoretic migration speed of particles in an electric field, combined with dynamic light scattering technology, the value of Zeta potential is obtained. Combined with the dynamic light scattering method, particle size, and Zeta potential information can be obtained simultaneously.
Ultrasonic electroacoustic method	By utilizing sound wave signals for testing, there is no requirement to dilute the sample as it can be directly tested in its original solution.
Streaming potential method	By measuring the fluid flow to strip the charge on the particles or interface, the value of Zeta potential is obtained. It is suitable for testing the Zeta potential of solid surfaces, hollow fiber interiors, membrane surfaces, etc. that are difficult to measure directly.
Electrophoresis method	By measuring the electrophoretic migration speed of particles in an electric field, the value of Zeta potential is calculated in combination with relevant formulas. It is one of the basic methods for measuring Zeta potential.

Our Advantages in Nano Transdermal Formulation Zeta Potential Testing

High precision and accuracy: We use advanced Zeta potential analyzers to ensure high precision and accuracy of test results.
Fast and convenient: Our test cycle is short, and we can provide test results quickly to meet customers' time needs.
Strong professionalism: We have rich experience in R&D, production, and quality control of nano-transdermal preparations and can provide professional technical support and consultation.
High degree of customization: We can provide customized test plans and data analysis reports according to customers' specific needs.

Published Data

Technology: Methods to nano transdermal formulation zeta potential testing

Journal: Pharmaceutics

IF: 5.4

Published: 2022

Results: Formulating nanomedicine with suitable zeta potential is an essential but challenging assignment. Formulations with a minimum ±30 mV zeta potential are considered stable. The study aimed to optimize liposomal formulations prepared via the thin-film hydration technique by applying stearyl amine (SA) or diacetyl phosphate (DCP) as charge-imparting agents.

Fig.2 Nano transdermal formulation stability tests. Fig.2 4-week stability tests in the optimized formulations hydrated with PBS pH 5.6 measured by dynamic light scattering: SA-PBS pH 5.6 (A) and DCP-PBS pH 5.6 (B). The changes in vesicle size, polydispersity, and zeta potential were followed. Results are from three independent parallels. (Zsófia Németh, et al. 2022)

By monitoring the changes in Zeta potential, we can help you optimize the formulation of nano transdermal preparations and improve the stability and performance of the preparations. If you have any needs, please feel free to contact us and our colleagues will contact you within three working days.

References

Zsófia Németh, Ildikó Csóka, et al. Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives. Pharmaceutics 2022, 14, 1798.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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