Testing the size distribution of nanoparticles in nano transdermal formulations is crucial to understanding their behavior, stability, and skin penetration potential, which is related to the permeability and therapeutic effect of drugs in the skin layer. CD Formulation can provide you with professional nano transdermal formulation size distribution testing.
As a new type of drug delivery system, nano transdermal preparations have broad application prospects in the field of drug research and development. The fluidity, ease of operation, and in vivo bioavailability of active pharmaceutical ingredients (APIs) and excipients are key requirements for drug preparations. The size distribution test of nano transdermal preparations has an important impact on ensuring drug efficacy, controlling drug release, improving drug safety, and optimizing formulation processes. Through accurate particle size distribution testing, the development and application of nano transdermal preparations can be promoted, and the development of the field of nanomedicine can be promoted.
Fig 1. Flow chart of nano transdermal formulation size distribution testing. (CD Formulation)
Ensure that the sample is evenly mixed and does not aggregate. Process according to sample characteristics, such as centrifugation to remove large particles. Calibrate the instrument.
Keep the laboratory environment at a constant temperature and humidity to avoid interfering with the test results.
Turn on the instrument power and add the sample to the sample pool. Perform the test according to the instrument operating instructions. It is usually necessary to enter sample information and test parameters, such as laser power, measurement time, etc.
After the test is completed, the data is processed and analyzed by the instrument's software or other data processing software to obtain the particle size distribution results.
Technologies | Description |
---|---|
Dynamic Light Scattering (DLS) | DLS measures the intensity fluctuations of scattered light caused by the Brownian motion of nanoparticles in solution. |
Static Light Scattering (SLS) | SLS measures the intensity of light scattered by nanoparticles at a fixed angle. |
Transmission Electron Microscopy (TEM) | TEM allows direct visualization of nanoparticles at the nanoscale. |
Scanning Electron Microscopy (SEM) | SEM provides high-resolution images of the surface of nanoparticles. |
Nanoparticle Tracking Analysis (NTA) | NTA uses light scattering to track the Brownian motion of nanoparticles in suspension. |
Technology: Methods to nano transdermal formulation size distribution testing
Journal: Oncotarget
IF: 5.2
Published: 2017
Results: In this study, an environment-responsive dye, P4, was loaded into nanoemulsions to track the transdermal translocation of the nanocarriers, while coumarin-6 was embedded to represent the cargoes. Particle size has great effects on the transdermal transportation of nanoemulsions. Integral nanoemulsions with a particle size of 80 nm can diffuse into but not penetrate the viable epidermis. Instead, these nanoemulsions can efficiently fill the whole hair follicle canals and reach as deep as 588 μm underneath the dermal surfaces.
Fig.2 Particle size distribution and morphology of nanoemulsions. A and a. NE-80; B and b. NE-200; C and c. NE-500. (Rui Su, et al. 2017)
CD Formulation provides you with high-accuracy, high-resolution, and high-sensitivity nanotransdermal preparation size distribution tests, ensuring the accuracy and reliability of the results, and providing strong support for your nano-drug research and development. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.
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