Nano Transdermal Formulation Drug Loading Testing

Transdermal drug delivery can help prevent issues like poor bioavailability or unwanted side effects in certain situations. Recent advancements in nano-transdermal drug delivery technology have made it possible to surpass the skin barrier without harming tissues and ensure successful drug absorption. CD Formulation has extensive expertise in developing nano transdermal formulations and offers expert drug-loading testing services.

What is Nano Transdermal Formulation Drug Loading Testing?

The drug loading test of nano transdermal formulations is designed to determine the amount of drug carried in the nanocarrier. The size of the drug loading directly affects the drug release efficiency and biological activity of the nanocarrier. It is an important indicator for evaluating the performance and application effect of nano transdermal formulations. It is of great significance for optimizing the preparation process of nano transdermal formulations and improving drug release efficiency and bioavailability.

What Can We Offer

Typically, our drug loading assessment involves separating drugs from carriers and quantitatively analyzing the drugs. This separation is achieved through physical or chemical means, followed by quantitative analysis of the drug using techniques such as high-performance liquid chromatography (HPLC), ultraviolet spectroscopy (UV), or other analytical methods to determine the drug content in the nanocarrier.

Drug loading = (drug mass/nanocarrier mass) × 100%

Our Workflow for Drug Loading Testing of Nano Transdermal Formulations

Fig.1 Flow chart of nano transdermal formulation drug loading testing. (CD Formulation)

1. Sample preparation: Prepare samples of nano transdermal formulations to ensure sample stability and consistency.

2. Separation of drugs from carriers: Use ultracentrifugation, ultrafiltration, or other physical methods to separate drugs from carriers. During the separation process, ensure that the drug can be completely released from the carrier to avoid the influence of drug residues on the test results.

3. Drug quantitative analysis: Utilize HPLC, UV, or alternative analytical techniques to quantitatively assess the isolated drugs and ascertain their concentration in the solution. When conducting quantitative analysis, select suitable analytical methods and parameters to guarantee the precision and dependability of the measurement outcomes.

4. Calculate drug loading: Calculate drug loading based on the concentration of the drug in the solution and the mass of the nanocarrier. To obtain more reliable results, perform multiple parallel tests on each batch. Then, calculate the mean and coefficient of variation of all test results to evaluate the stability and repeatability of the data.

Our Technology Platform

Our Advantages in Nano Transdermal Formulation Drug Loading Testing

• We are equipped with advanced analytical instruments and equipment, which can accurately and quickly quantify the drug content in nanoformulations to ensure the reliability and accuracy of the data.
• We have professional technicians and testing teams who have rich knowledge of nanotechnology and drug analysis and are proficient in various testing methods and standard operating procedures.
• We can provide personalized testing services according to the specific needs of customers, such as customized testing solutions, rapid testing services, etc.

Published Data

We provide you with comprehensive, professional and reliable nano transdermal formulation drug loading testing services. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.