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In Vitro Release Testing of Transdermal Formulation

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In vitro drug release refers to the speed and degree of release of the active drug from the transdermal patch under specified conditions in vitro. The in vitro release test (IVRT) is usually used to evaluate the drug release degree of the transdermal patch. CD Formulation can provide you with professional in vitro release testing of transdermal formulation.

About In Vitro Release Testing of Transdermal Formulation

In vitro release test is an effective means to characterize and evaluate the properties of transdermal formulation. The degree and speed of local release of topical drugs in vitro is a comprehensive reflection of the properties of the formulation, including the solubility, particle size and rheological properties of semi-solid formulations, etc., which is mainly used for the pharmaceutical quality control of topical formulations. In vitro release rate can reflect the comprehensive effect of various physicochemical parameters such as solubility, particle size and rheology of dosage form, and can identify the influence of prescription and process changes on the formulation.

Our Workflow for In Vitro Release Testing of Transdermal Formulation

Our general process for in vitro release testing of transdermal patches is as follows:

Workflow for in vitro release testing of transdermal formulations. Fig.1 Flow chart of in vitro release testing (CD Formulation)

Our Technology Platform

At CD Formulation, our commonly used in vitro release testing methods mainly include the following:

Technology	Description
Paddle-disc method	The paddle-disc method is a commonly used in vitro release testing method for transdermal patches. We use stainless steel mesh dishes or polytetrafluoroethylene mesh to fix the transdermal patch with the drug release side facing up between the mesh dishes. Then conduct an in vitro release experiment, which can simulate the release process of the transdermal patch on human skin to evaluate its release degree.
Rotating drum method	The rotating drum method uses a stainless steel cylinder to fix the transdermal patch with the drug-releasing surface facing outwards on the outside of the rotating cylinder, and then places it in the dissolution medium. The rotation of the drum simulates the relative movement between the skin and the patch to evaluate the release of the patch. The method is suitable for larger transdermal patches.
Diffusion cell method	This method uses a modified Franz diffusion cell and uses isolated human skin or animal skin to simulate the skin flux of drugs through human skin to evaluate the in vitro release performance of transdermal patches.

Why Choose Us for In Vitro Release Testing of Transdermal Formulation?

The release of a drug from a preparation is the first step in exerting its efficacy. The extent and speed of local release of external drugs in vitro are a comprehensive reflection of the performance of the formulation. We use sensitive in vitro release methods to help customers identify subtle changes in formulation composition, physical properties, microstructure and formulation processes. Our detection method has the following advantages:

Characterize the drug release performance of the formulation and use it for the formulation design and optimization of the formulation.
Used as a quality control method to ensure product quality between batches and used to evaluate product equivalence for scale-up and post-approval changes.

Published Data

Technology: Methods to in vitro release testing of transdermal formulation

Journal: Hindawi Publishing Corporation

IF: 4.3

Published: 2012

Results: In the study, In the present work, a new method for measuring drug release from patches has been explored and compared with the conventional USP apparatus 2 and 5 methods. The drug concentrations in the extractions were measured by isocratic reverse phase high-pressure liquid chromatography. The results showed that, with the increasing moisture level on the synthetic skin simulator, the drug release rate increased.

Methods of in vitro release testing of transdermal formulations. Fig.2 Illustration of the SSS method setup (Bing Cai, et al., 2012)

In vitro release tests can simulate the drug release behavior of transdermal patches on human skin to predict drug release and absorption in the body. This is of great significance for evaluating the therapeutic effect of transdermal patches, formulating dosage regimens, and guiding clinical medication. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

Bing Cai, Karin Soderkvist, et al. A New Drug Release Method in Early Development of Transdermal Drug Delivery Systems. Hindawi Publishing Corporation. 2012, Article ID 953140, 6 pages.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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