The purpose of developing protein and peptide drug delivery systems is to find an optimal way to deliver drugs to the target tissue or organ to the greatest extent while meeting treatment needs, thereby improving the therapeutic effect of the drug, reducing toxic and side effects, and providing clinical benefits treatment brings more choices and possibilities. CD Formulation masters the cutting-edge technology and expertise in the development of therapeutic protein and peptide formulations and drug delivery systems, and is committed to providing comprehensive and systematic solutions to the pharmaceutical industry, including but not limited to oral, transdermal, injection, inhaled, intranasal, targeted, etc.

About Proteins & Peptides Drug Delivery System Development

Therapeutic proteins and peptides, as a new type of therapy, have been widely used in a variety of diseases. The gastrointestinal route, i.e. injection, is its most common method of administration. However, due to its short half-life in the body, frequent injections are required, resulting in poor patient compliance. There is therefore an urgent need to explore multiple different drug delivery routes to meet the needs of different diseases and patients. Currently, various non-invasive routes of drug delivery such as transdermal, nasal, pulmonary, and oral are becoming increasingly popular and offer various advantages over parenteral drug delivery. However, the inherent structural instability and low permeability of therapeutic proteins and peptides limit drug delivery via these non-invasive delivery routes. Nanoparticles have become an active area of research as innovative delivery technologies to facilitate absorption through non-invasive routes and improve the bioavailability of proteins and peptides.

Fig. 1 Peptide-based drug delivery systems. (Berillo D, et al., 2021)

Explore Our Proteins & Peptides Drug Delivery System Development Services

CD Formulation is a leading pharmaceutical company focused on the development of therapeutic protein and peptide formulations and delivery systems. With decades of formulation development and continuous exploration and extensive research on protein and peptide drug delivery systems, we aim to provide customers with efficient and safe therapeutic protein and peptide formulation and delivery system solutions.

The design and development of our proteins and peptides drug delivery systems will comprehensively consider many factors of your drug molecules, such as physical and chemical properties, targeting properties, biological stability, drug release speed, and application fields, etc., to ensure the best drug delivery effects and therapeutic effects.

Importantly, our team of highly qualified scientists also uses advanced technologies and methods, such as nanotechnology, chemical modification technology, chemical synthesis technology, microneedle technology, etc., to optimize drug delivery systems to achieve precise, durable, and safe drug release molecules into target cells or tissues.

Our proteins & peptides drug delivery system development services including but are not limited to:

• Proteins & Peptides Oral Delivery System Development
• Proteins & Peptides Transdermal Delivery System Development
• Proteins & Peptides Injectable Delivery System Development
• Proteins & Peptides Inhaled Delivery System Development
• Proteins & Peptides Intranasal Delivery System Development
• Proteins & Peptides Innovative Delivery System Delivery Development

Fig. 2 Proteins & peptides drug delivery system development services. (CD Formulation)

General Workflow of Our Proteins & Peptides Drug Delivery System Development

• Characterization of therapeutic proteins and peptides, including solubility, primary and higher-order structures, amino acid sequences, post-translational modifications, and aggregation analysis.
• Screen the best drug delivery method according to the application route, including conventional oral delivery, transdermal delivery, injection administration, inhalation delivery, etc.
• Once the optimal delivery route for the target ingredient is determined, our team of experts will test different types of excipients to evaluate their impact on the stabilization of the therapeutic protein and peptide to screen for the best buffers and excipients to stabilize the protein and peptide.
• On this basis, formulation studies are conducted, and drug release in vitro and in vivo is tested, drug release kinetics of different delivery systems are evaluated, and the optimal release mechanism is determined to achieve sustained drug release.
• The optimal delivery system is identified, we will conduct in vivo pharmacodynamic studies to evaluate the bioavailability, drug distribution, pharmacodynamics, and safety of the drug in animal models to determine the effectiveness and safety of the delivery system.
• Preclinical studies, including toxicology studies and drug effectiveness studies, ensure the safety and effectiveness of the delivery system.

Why Choose Us for Proteins & Peptides Drug Delivery System Development?

• Decades of experience and achievements in the development of therapeutic protein and peptide drug formulations and drug delivery systems.
• Master the latest expertise in therapeutic protein and peptide formulations and drug delivery systems.
• Support the development of a variety of therapeutic protein and peptide drug delivery systems, including but not limited to oral, transdermal, injection, inhaled, intranasal, targeted, etc.
• The design and optimization of a variety of innovative delivery vehicles, including liposomes, microneedles, polymers, hydrogels, polysaccharides, etc., ensure the smooth implementation of various therapeutic protein and peptide drug delivery system projects.
• Advanced technical means include nanotechnology, microfluidic, bioengineering, etc.
• Flexible experimental design and customized solutions.

Publication

CD Formulation masters the most advanced technology and industry knowledge in the development of therapeutic protein and peptide delivery systems and is committed to providing customers with high-quality, innovative, and reliable solutions to help them achieve their drug delivery goals. Please don‘t hesitate to contact us if you are interested in our services.