Here's how you can reach us...
  • Tel:
  • Email:

X-ray Diffraction (XRD) Analysis for Oral Thin Film

Inquiry

The X-ray diffraction (XRD) analysis for oral thin films is a critical technique for characterizing the crystalline structure of the active pharmaceutical ingredients and other solid-state components in the thin film, which can help to determine the crystal or amorphous nature of the drugs included in the thin film. In this way, it can be checked whether the drugs in the oral thin film have undergone any changes in the preparation process of their conformational sequences and whether they have turned into other polymorphs, this is very important for formulation development, stability, and product quality of the oral thin film. CD Formulation provides professional XRD analytical techniques to meet the specific needs of oral thin films.

Fig.1 X-ray diffraction patterns of AR-FNB powder, placebo film, and the films.Fig.1 XRD patterns of AR-FNB powder, placebo film, and the films. (Guluzar G. Buyukgoz , et al., 2021)

The Importance of XRD Analysis for Oral Thin Film

The XRD is a common method used to analyze the properties of oral thin films, XRD can provide information about the film's:

  • Crystalline or amorphous nature
  • Structural characteristics
  • Degree of crystallinity
  • Geometry and size of repeating structures
  • Quality, orientation, and thickness

Our Oral Thin Film XRD Analysis Services

CD Formulation is committed to delivering valuable insights into the solid-state properties of oral thin films, aiding in formulation development and quality control.

Fig.2 Oral thin film X-ray diffraction (XRD) analysis.Fig.2 Our Oral Thin Film XRD Analysis Services. (CD Formulation)

Crystalline Phases Identification: Our XRD analysis can help our clients identify and characterize crystalline phases present in oral thin films, and help our clients determine the degree of crystallinity and amorphous content in samples.

Polymorph Identification: Our XRD analysis can help our clients identify and characterize different polymorphs of the active pharmaceutical ingredients present in the oral thin film.

Structural Evaluation: Our XRD analysis can assess the uniformity and homogeneity of the thin film structure, evaluate the impact of formulation and processing parameters on the crystalline structure of the thin films, and investigate the stability and potential phase transformations of the thin film formulations.

Our Workflow of Oral Thin Film XRD Analysis

We can provide professional oral thin film XRD analysis proposals and testing services from the following steps:

Fig.3 Our workflow for oral thin film X-ray diffraction (XRD) analysis.Fig.3 Our Workflow for Oral Thin Film XRD Analysis Services. (CD Formulation)

Advantages of Our Oral Thin Film XRD Analysis

  • Cutting-edge Technology: We utilize state-of-the-art XRD equipment to analyze the solid-state characteristics of oral thin films, providing high-resolution data to meet research and development needs.
  • Expertise: Our team of skilled analysts has extensive experience in XRD analysis, ensuring accurate interpretation and insightful recommendations for oral thin film formulations and manufacturing processes.
  • Quick Turnaround: We offer rapid analysis and reporting to meet project timelines, providing timely data to support the development of oral thin film.

Published Data

Technology: Wide Angle XRD Studies

Journal: AAPS PharmSciTech

IF: 3.3

Published: 2017

Results: In this study, XRD patterns for pure ingredients and selected mucoadhesive medicated films as well as their corresponding physical mixture were recorded using an X-ray diffractometer equipped with CuKα as the source of radiation. It was observed that the pure drug exhibited a diffraction pattern with numerous distinctive peaks indicating its highly crystalline state. The most abundant peaks were observed at 2θ values of 9.8°, 13.0°, and 15.0° and peaks of lower intensity 2θ values at 16.5°, 18.0°, 21.0°, and 22.0°.

Fig.4 X-ray diffraction spectra of fluticasone propionate.Fig.4 X-ray diffraction spectra of fluticasone propionate. (Hussein O. Ammar, et al., 2017)

With state-of-the-art XRD analysis equipment and experienced analysts, CD Formulation provides high-resolution data to support clients' research and development needs. If you require our oral thin film XRD analysis services, please contact us by phone or email, and our colleagues will get back to you within three working days.

References

  1. Hussein O. Ammar, Mahmoud M. Ghorab, et al. Design and In Vitro/In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate. AAPS PharmSciTech. 2017, Vol(18):93-103.
  2. Anroop B. Nair, Jigar Shah, et al. Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation. Pharmaceutics. 2021, 13(5).
How It Works
STEP 2
We'll email you to provide your quote and confirm order details if applicable.
STEP 3
Execute the project with real-time communication, and deliver the final report promptly.
Related Services

CD Formulation, an expert in novel oral thin film delivery systems, is dedicated to supporting pharmaceutical companies in developing and commercializing innovative drug formulations...

Learn More

  • Tel:
  • Email:

Stay up to date with our latest releases of new research and promotions.

Copyright © CD Formulation. All Rights Reserved.