Solvent Casting Method for Oral Thin Film Preparation

The solvent casting method is the most commonly used preparation technology, and its process is simply to dissolve or suspend film-forming materials, raw materials, and other excipients in appropriate solvents, such as water, ethanol, acetone, etc. The air bubbles are removed after mixing evenly, and then cast on the mold or coated with the film-forming agent and cut and packaged after drying. With years of development, CD Formulation has established a solvent casting platform based on experienced experts and advanced instruments.

Fig.1 Flow chart illustrating the various processes typically involved in buccal film manufacturing based on solvent casting technique. (Shery Jacob, et al., 2021)

The Advantages of the Solvent Casting Method for Oral Thin Film Preparation

• The preparation process is simple and cost-effective.
• The thickness of the film is uniform, and the films produced are quite thin (12-100 µm).
• The films have a good glossy appearance and better physical properties.
• The films are quite flexible.

Key Factors of Solvent Casting Technology

For the raw materials of the dope-making process, there are some obvious prerequisites.

• The polymer must be soluble in a volatile solvent or water.
• A stable solution with a reasonable minimum solid content and viscosity should be formed.
• Formation of a homogeneous film and release from the casting support must be possible.

Fig.2 Production of solvent cast films. (U.Siemann, 2021)

Our Solvent Casting Process for Oral Thin Film Preparation

The solvent casting method is the most common approach for preparing oral thin films using water-soluble excipients, polymers, and drugs dissolved in deionized water. A uniform mixture is obtained by applying a high shear force generated by the shear processor. The prepared solution is then poured onto a petri dish and exposed to high temperatures to dry, resulting in a high-quality film.

 Fig.3 Workflow of solvent casting method for oral thin film preparation. (CD Formulation)

Why Choose Us for Preparing Oral Thin Films with the Solvent Casting Method?

• Low MOQ: Our solvent casting method has a low minimum order quantity (MOQ), making it ideal for customers with limited budgets and small order requirements.
• Advanced Instrument: We use the most advanced instruments, ensuring that the entire production process is continuous, accurate, and controllable.
• Professional Team: We have professional solvent casting technicians who regularly check and maintain the equipment.

Published Data

Our professional solvent casting technology platform can provide you with sample trial production help for the development of oral thin film process. If you have a requirement about our solvent casting method for oral thin film preparation services, please contact us by phone or email, and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.