Saliva Stimulant Screening of Oral Thin Film

The oral thin films are especially suitable for patients with mental disorders, Alzheimer's disease, allergy immunotherapy, nicotine dependence, pain medication dependence, and other swallowing difficulties. Saliva stimulants are an essential ingredient in the formulation of oral thin films. The purpose of using saliva stimulant is to increase the rate of saliva production, which will help the oral thin film decompose faster. According to the nature of the drug ingredients, CD Formulation can provide professional saliva stimulant screening for oral thin film services.

Why Use Saliva Stimulant in Oral Thin Film?

Saliva stimulants tend to speed up the disintegration of formulations by increasing saliva intake. In general, saliva stimulants can usually be found in food-grade acids, citric acid, malic acid, lactic acid, ascorbic acid, and tartaric acid are several common salivary stimulants, with citric acid being the most popular.

Fig.1 Saliva stimulating agents, malic acid (22a), lactic acid (22b), ascorbic acid (22c), and tartaric acid (22d), (Manasa Chandramouli, et al., 2023)

Our Saliva Stimulant Screening for Oral Thin Film Development

CD Formulation based on the type of oral thin film, preparation process, and API properties, comprehensively evaluates and screens the most suitable saliva stimulant from the following aspects to ensure the quality and efficacy of oral thin films and achieve good therapeutic effects:

Taste Evaluation

Saliva stimulants usually have a certain sour taste, we combine the flavoring agent and sweeteners in the oral thin film to evaluate the optimal saliva stimulant and the amount to add to obtain an oral thin film with good taste.

Dissolution Evaluation

Different saliva stimulants will affect the production rate of saliva, and then affect the release of drugs. A typical in vitro dissolution test is used to evaluate the influence of saliva stimulants on film agents.

Compatibility with Other Excipients

Saliva stimulants may react with some excipients, for example, citric acid will decompose into various products under heating conditions, and react with glycerin, alkali, etc. We will screen suitable saliva stimulants according to the preparation process of oral thin film and the properties of raw materials and excipients.

Our Platforms for Oral Thin Film Saliva Stimulant Screening

Advantages of Our Saliva Stimulant Screening Services

• Efficient Screening Process: We have an efficient screening process for saliva stimulants to speed up your oral thin film development.
• Rich Experience: We have many years of research and service experience in oral thin film drug development. We are familiar with the properties of various raw materials and excipients and can adjust the saliva stimulant at any time according to the preparation process of oral thin films.
• High-quality Partners: We have a strict quality control system to ensure that the entire screening process complies with regulatory requirements.

Published Data

CD Formulation can bring the most professional saliva-stimulating screening technical guidance for customers. If you have a requirement about our saliva stimulating screening for oral thin film services, please contact us by phone or email, and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.