Rolling Method for Oral Thin Film Preparation

The rolling method is a technique for manufacturing oral thin films, that involves rolling a solution or suspension containing the drug onto a carrier. The solvent is usually water or a mixture of water and alcohol, and the film is then dried on the rollers and cut into the desired shapes and sizes. The dispersions are shaped into films using dies. As a leader in innovative drug development, CD Formulation has established a rolling technology platform to assist in the development and production of oral thin film drugs.

Fig.1 Rolling method. (Dalia Abd Elaty Mostafa, et al., 2018)

The Advantages of the Rolling Method for Oral Thin Film Preparation

• Fewer operation units
• Better content uniformity
• The thickness of the film is controllable.
• The film is clear and bright.

Our Rolling Method Process for Oral Thin Film Preparation

In the rolling process, film is created by first preparing the pre-mix, then adding the active ingredient, and then forming the film. The pre-mix batch is introduced to the main batch feed tank together with additional materials such as polar solvent, film-forming polymer and API. The first metering pump and control valve then feed a predefined amount of the masterbatch. Once the mixer is filled with the proper amount of medication, it is combined long enough to create a homogenized matrix. The second metering pump feeds a certain amount of matrix into the pan. The film thickness is measured by the metering roller. At last, the film is produced on the substrate and removed by the support roller.

 Fig.2 Workflow of Rolling Method for Oral Thin Film Preparation. (CD Formulation)

Why Choose Us for Preparing Oral Thin Films with the Rolling Method?

• Flexibility: We use state-of-the-art rolling manufacturing processes, our MOQ is flexible, and we can produce according to customer's demand.
• State-of-the-art Instrument: We use the most advanced instruments, and the entire production process is continuous, accurate, and controllable.
• Rich Experience: We have many years of experience in the rolling production of oral thin film, we can quickly help customers solve the possible problems in this preparation technology and speed up the development of oral thin film.

Published Data

CD Formulation can help you solve any problems that arise in the rolling method to prepare the oral thin film. If you have a requirement about our rolling method for oral thin film preparation services, please contact us by phone or email, and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.