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Oral Thin Film Young’s Modulus Testing

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The Young's modulus is in essence the stiffness of a material. In other words, it is how easily it is bent or stretched, and it is represented as the ratio of the stress applied over the strain in the area of elastic deformation. Higher Young's modulus indicates that the material is harder, which helps the oral film maintain its shape and integrity during management and use. CD Formulation provides comprehensive Young's modulus solutions and expertise to facilitate oral thin film formulation development and comply with processing requirements.

Importance of Oral Thin Film Young's Modulus Testing

Young's Modulus is the measure of the stiffness of the film strip, it is represented as the ratio of the stress applied over strain in the area of elastic deformation. It is calculated by the following equation:

Young modulus = Force of corresponding strain/ cross

Its testing helps determine the structural integrity and mechanical properties of oral thin film, understand performance under different conditions, and optimize formulations.

Fig.1 The Benefits for Testing Oral Thin Film Young's Modulus.Fig.1 The Importance of Oral Thin Film Young's Modulus Testing. (CD Formulation)

Our Oral Thin Film Young's Modulus Testing Services

At present, there are many methods to measure Young's modulus of oral thin film, and we often use nano-indentation method, tensile testing method, dynamic mechanical analysis method, etc.

Tensile Testing Method

Tensile testing includes applying a controlled force to an oral thin film sample and measuring the resulting deformation, and Young's modulus of the thin film can be obtained by analyzing the stress-strain curve.

Nano-indentation Method

The nanoindentation method is a commonly used measurement method of Young's modulus in thin films. The corresponding load-displacement curve is obtained by continuously measuring the displacement and load acting on the indenter, and by analyzing the curve and data, we can obtain Young's modulus of the oral thin film sample.

Dynamic Mechanical Analysis (DMA)

DMA is a widely used method to measure Young's modulus of thin film. It has the advantages of fine measurement and simple calculation. This method involves subjecting oral thin film to oscillatory stress or strain and measuring the resulting mechanical response, and we can obtain the Young's modulus of thin film by analyzing the changes of the storage modulus and loss modulus with frequency.

Our Workflow of Oral Thin Film Young's Modulus Testing

Our team can quickly respond to customers' oral thin film Young's modulus testing requirements to support their oral thin film development needs, and we have standardized testing procedures, and our Young's modulus testing workflow is as follows:

Fig.2 Workflow of Oral Thin Film Young's Modulus Testing.Fig.2 Workflow of Oral Thin Film Young's Modulus Testing. (CD Formulation)

Our Advantages in Testing Oral Thin Film Young's Modulus

  • Expertise: Our team of experienced professionals has a deep understanding of the testing methods and techniques required to accurately determine Young's modulus of oral thin films. We have the knowledge and skills to conduct tests efficiently and interpret results effectively.
  • Advanced Equipment: We have cutting-edge instrumentation and technology to ensure precise measurements and reliable data, allowing us to deliver high-quality results to our clients.
  • Timely Delivery: Our streamlined processes and efficient testing protocols enable us to deliver accurate Young's modulus data for oral thin films within the agreed-upon time frame.

Published Data

Technology: Young's Modulus Testing

Journal: Journal of Drug Delivery Science and Technology

IF: 2.7

Published: 2019

Results: In this study, the eight silodosin oral films developed (F1–F8) contained 8 mg silodosin per 6 cm2 film and HPMC or HPMC-AS in drug. The films were characterized using DSC, TGA, SEM, and PXRD and the mechanical properties were investigated by measuring tensile strength, elongation at break and Young's modulus. The results show that mechanical properties of the films were dependent on the ratio of polymer used.

CD Formulation provides professional oral thin film Young's modulus testing solutions. If you have a requirement about our oral thin film Young's modulus testing services, please contact us by phone or email, and our colleagues will reply to you within three working days.

References

  1. Amani Alhayali, Parameswara Rao Vuddanda, et al. Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva. Journal of Drug Delivery Science and Technology. 2019, Vol (53).
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