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Oral Thin Film Transparency Testing

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As a new type of drug dosage form, the oral film is deeply loved by patients, but its appearance will also directly affect the user experience of patients, among which transparency is an important indicator of appearance tests, because it will affect the beauty of the product and the acceptance of patients. CD Formulation offers a variety of methods for testing the transparency of oral thin film, and we choose the most appropriate method according to the type and needs of customers.

Importance of Oral Thin Film Transparency Testing

Fig.1 The Importance of Oral Thin Film Transparency Testing.Fig.1 The Importance of Oral Thin Film Transparency Testing. (CD Formulation)

Our Oral Thin Film Transparency Testing Services

We can offer different transparency testing methods relying on our extensive experience in the analysis of oral thin film.

Visual Inspection Method

This is a simple and qualitative method of visually inspecting thin film for turbidity, opacity or visible particles. This method can provide a general indication of thin film transparency and does not provide a precise measurement.

Transmittance Measurement Method

This method involves measuring the amount of light transmitted through the film using an ultraviolet (UV) spectrophotometer. Oral thin film samples are cut rectangularly and placed inside the UV spectrophotometer cuvette. The permeability of the film is made at a wavelength of 600 nm. The following equation is used for the results obtained:

Transparency=logT600/b
(T600 = Transmittance at 600 nm, b = film thickness(mm)

Haze Measurement Method

Haze is a measure of the scattering of light as it passes through thin film, which can quantify the degree of cloudiness or haziness in thin film and be used to indicate the transparency of thin film.

Our Capabilities for Testing Oral Thin Film Transparency

Transparency Testing Detailed Information
Ultraviolet Spectrophotometer (UVS) The UVS is a very specialized type of light meter that is sensitive to ultraviolet light. We use UVS to measure the absorbance or transmittance of light in the ultraviolet wavelength range of thin film samples to evaluate the transparency of oral thin film samples.
Haze Meter The haze meter is a commonly used instrument for measuring haze or cloudiness. The haze meter quantifies the scattering of light as it passes through the film, providing an objective measurement of the film's transparency.

Our Advantages in Testing Oral Thin Film Transparency

  • We have been researching the development and analysis services of oral thin film for many years, and we have a professional analysis team, which can help customers accurately assess the transparency of oral thin film and provide valuable insights and recommendations based on test results.
  • We have advanced transparency testing equipment, including UV spectrophotometer, haze meter, etc., which can provide accurate and reliable results.
  • We also provide our customers with transparency testing method development and validation services when it is necessary.
  • We provide detailed testing reports, including clear and concise information about the testing methodology, measurements, observations., etc.

Published Data

Technology: Transparency analysis

Journal: Gels

IF: 4.6

Published: 2023

Results: In this study, transparency analysis was performed for each OTF formulation; the results show that the transparency of OTF formulations (such as F1, F6, F7, F11, and F12) prepared alone or in a combination of cellulose derivatives (such as sodium carboxymethyl cellulose, hydroxypropyl methylcellulose (HPMC E15) and pullulan as polymers were found to be significantly different compared to ones prepared with other polymers (p < 0.05).

Fig.2 Preparation and Characterization of Fast Dissolving Thin Films.Fig.2 Preparation, Characterization of Fast Dissolving Hydrogel Based Oral Thin Films. (Emrah Özakar, et al., 2023)

CD Formulation has advanced analytical design concepts and a strong team with rich experience to provide transparency testing services during your oral thin film development. If you have a requirement about our oral thin film transparency testing services, please contact us by phone or email, and our colleagues will reply to you within three working days.

References

  1. Emrah Özakar, Rukiye Sevinç-Özakar, et al. Preparation, Characterization, and Evaluation of Cytotoxicity of Fast Dissolving Hydrogel Based Oral Thin Films Containing Pregabalin and Methylcobalamin. Gels. 2023, 9(2): 147.
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CD Formulation, an expert in novel oral thin film delivery systems, is dedicated to supporting pharmaceutical companies in developing and commercializing innovative drug formulations...

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