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Oral Thin Film Moisture Content Testing

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Abnormal moisture content will affect the quality and efficacy of oral thin film products, if the moisture content is too high, it will seriously affect products' stability, physical and chemical properties, effectiveness, and expiration date. Taking such drugs will endanger health and life safety, therefore, the quantitative of moisture has become one of the basic items of oral thin film inspection. CD Formulation provides moisture content testing services for oral thin films to ensure the physical and chemical stability and pharmacological activity of thin-film products and minimize potential formulation and stability issues.

The Importance of Oral Thin Film Moisture Content Testing

The moisture in oral thin film includes crystal water and adsorbed water, and the moisture content impacts the physical and chemical properties, preparation process, stability, selection of packaging materials, and efficacy of oral thin film products.

Our Oral Thin Film Moisture Content Testing Techniques

According to the type and composition characteristics of oral thin film, CD Formulation explored a variety of moisture content testing methods, including but not limited to the following methods:

Testing Methods	Detailed Information
Atmospheric Drying Method	This method accurately measures the weight of the sample before and after heating at normal pressure and a certain temperature and calculates the relative moisture content.
Vacuum Drying Method	This method accurately measures the weight of the sample before and after heating at a selected vacuum degree and drying temperature and calculates the relative moisture content.
Thermogravimetric Analysis Method	This method accurately measures the weight of the sample within a specific temperature range under program-controlled temperature and calculates the relative moisture content.
Karl-Fisher Method	This method is when iodine oxidizes sulfur dioxide, it requires a certain amount of water, and the water content can be measured from the amount of iodine consumed.
Gas Chromatography	In this method, water vapor and ethanol are separated by different partition coefficients between the mobile phase (carrier gas) and the stationary phase, and the water content in the sample is calculated by the external standard method.

Our Workflow of Oral Thin Film Moisture Content Testing

We have a professional oral thin film moisture content testing team and standardized testing procedures, which can quickly respond to customers' testing needs. Our testing process is as follows:

Fig.1 Process of Oral Thin Film Moisture Content Testing. (CD Formulation)

Preparation Before Experiment: We will communicate with customers about their testing needs and make detailed experimental plans.

Establish Testing Method: Establish an analytical method based on analytical objectives and requirements.

Sample Preparation: Prepare the sample according to the instrument requirements and analysis method.

Analysis: Set the instrument parameters and put in samples for testing.

Data Analysis and Report: After completing sample analysis, analyze and process the data, and write a report.

Advantages of Our Oral Thin Film Moisture Content Testing

We are committed to providing different solutions for moisture content testing methods of oral thin film to help customers develop high-quality products.
Our analytics team has rich experience in oral thin film moisture content testing.
Our analytical team is familiar with the characteristics of each moisture test method and depending on the requirements of our customers and the type of oral thin film, we can choose a moisture test method that is specific, reproducible, and accurate to provide accurate test results.

Published Data

Technology: Moisture content evaluation

Journal: Journal of In Silico & In Vitro Pharmacology

IF: 2.7

Published: 2016

Results: In this study, prepare the fast-dissolving strips by solvent casting method with the selection of HPMC E5, E15, K15, and Microcrystalline Cellulose (MCC), Polyvinyl Alcohol (PVA) as polymers and glycerol as plasticizer. Prepare films were carried out for in vitro evaluation tests such as estimation of moisture content, etc. The data indicates that low moisture content ensures stability and prevents the formation of dried and brittle films.

Table. 1 Physical properties of the prepared oral thin films. (Venkateswarlu K, 2016)

Table.1 Physical properties of the prepared oral thin films.

As a leader in the field of oral thin film, CD Formulation not only provides customers with professional moisture content testing services and guidance for oral thin film formulation development based on the moisture content test results. If you require our moisture content testing services, please contact us by phone or email, and our colleagues will get back to you within three working days.

References

Venkateswarlu K. Preparation and Evaluation of Fast Dissolving Buccal Thin Films of Bufotenin. Journal of In Silico & In Vitro Pharmacology. 2016, Vol(2):1-5.
K. VIJAYA SRI, P. ROHINI, et al. MONTELUKAST SODIUM ORAL THIN FILMS: FORMULATION AND INVITRO EVALUATION. Asian J Pharm Clin Res. 2012, Vol(5):266-270.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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