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Oral Thin Film Moisture Absorption Testing

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CD Formulation provides a standardized testing procedure to determine the moisture absorption properties of oral thin film and evaluate its moisture absorption performance in humid environments, providing guidance for the transportation and storage of oral thin film.

Importance of Oral Thin Film Moisture Absorption Testing

The moisture absorption of oral thin film will promote the growth of microorganisms, which will affect the appearance, stability, effectiveness, safety, and other external and internal qualities of the thin film preparation, so it is important to study the moisture absorption of the thin film preparation.

Fig.1 The Importance of Oral Thin Film Moisture Absorption Testing.Fig.1 The Importance of Oral Thin Film Moisture Absorption Testing. (CD Formulation)

Our Oral Thin Film Moisture Absorption Testing Services

The physical stability of oral thin film at high humidity conditions can be checked by moisture absorption testing. The moisture absorption testing method typically involves saturated sodium chloride method and dynamic vapor sorption (DVS) method.

Saturated Sodium Chloride Method

The moisture absorption testing methods typically involve exposing the sample to a dryer containing a saturated solution of sodium chloride for a period of time. After the exposure period, the sample is weighed to determine the amount of moisture it has absorbed. The percentage of moisture absorption is calculated through the equation formula.

DVS Method

Another more accurate moisture absorption testing method is the DVS method, and our DVS method testing procedure is as follows:

Fig.2 Process of Oral Thin Film Moisture Absorption Testing.Fig.2 Process of Oral Thin Film Moisture Absorption Testing. (CD Formulation)

Our Capabilities for Testing Oral Thin Film Moisture Absorption

Moisture Absorption Testing Detailed Information
Dynamic Vapor Sorption (DVS) DVS is an advanced moisture adsorption testing equipment, it analyzes the sample's ability to adsorb moisture by the adsorption isotherm of the sample at a specific temperature and pressure. During the testing, the instrument control system automatically adjusts the sample temperature and humidity according to the preset program, thereby achieving dynamic testing of the sample's moisture adsorption performance.

Our Advantages in Testing Oral Thin Film Moisture Absorption

  • Our oral thin film moisture absorption testing services are conducted with precision and accuracy to provide reliable results.
  • Our team of experts has extensive experience and knowledge in oral thin film formulations, allowing us to conduct thorough moisture absorption testing with an understanding of the specific requirements and challenges of this type of product.
  • We utilize advanced instruments and equipment to perform moisture absorption testing, ensuring the highest quality and accuracy of the results.
  • We strive to provide fast and efficient testing services, allowing our clients to quickly assess the moisture absorption characteristics of their oral thin film products.

Published Data

Technology: Moisture Absorption Testing

Journal: Asian Journal of Pharmaceutical and Clinical Research.

IF: 10.2

Published: 2012

Results: In this study, montelukast fast-dissolving oral thin films were prepared by solvent casting method with different film-forming agents like HPMC, PVP, PEG 400, glycerol as a plasticizer and mannitol as filler and sweetener. The Percentage moisture absorption (PMA) test was carried out to check the physical stability of films in high humid conditions. In the present study, the moisture absorption capacity of the MTS films was determined by keeping the preweighed films in a desiccator at room temperature for 72 hours. Then they were taken out and exposed to 79.5% relative humidity (saturated solution of aluminum chloride). The results show that the percentage of moisture absorption varied within the range of 2.45 to 5.21%.

Table.1 The moisture absorption of the formulations. (K.VIJAYA SRI, et al., 2012)

Table.1 The moisture absorption of the formulations.

Our state-of-the-art equipment and expert technicians can accurately analyze moisture absorption of oral thin films, providing guidance for transportation and storage of oral thin films. If you have a requirement about our oral thin film moisture absorption testing services, please contact us by phone or email, and our colleagues will reply to you within three working days.

References

  1. K.VIJAYA SRI, P.ROHINI, et al. MONTELUKAST SODIUM ORAL THIN FILMS: FORMULATION AND INVITRO EVALUATION. Asian Journal of Pharmaceutical and Clinical Research. 2012, Vol(5).
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