Non-Disintegrating Buccal Film Development

The non-disintegrating buccal film will not dissolve when it comes into contact with saliva, and the APIs are continuously released under control. It is developed as a promising dosage form, which has prominent advantages because of drug delivery through the buccal mucosa. CD Formulation has many years of experience in the development of oral thin films, and our professional technical teams and advanced development platform can efficiently develop the non-disintegrating buccal film.

Fig.1 Rizatriptan loaded hydrogel-based mucoadhesive buccal film. (Shery Jacob, et al., 2021)

Why Develop Non-Disintegrating Buccal Film?

• The sublingual and buccal delivery of a drug via thin films has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile of the medicament.
• Non-disintegrating buccal film is more advantageous as our technical teams can deliver sustained and stable release of drug ingredients through customized drug release profiles.
• Each strip guarantees the accuracy of the dose administered compared to drop or syrup preparations.
• Compared with tablets, the fundamental benefit of a non-disintegrating buccal film is that its wide surface area enables rapid moistening of the film and rapid and constant release of active ingredients, thereby accelerating drug absorption.
• The buccal mucosa has an abundant blood supply and is an ideal and rapid location for drug absorption.

Our Non-Disintegrating Buccal Film Development Services

Formulation Design

During the formulation design phase of the non-disintegrating film, we need to focus on the adhesion testing, our team of experts will evaluate the suitability of excipients and adhesion properties so that some new copolymers can be selected as biomimetics for adhesion tests more cost-effectively. In addition, we also pay attention to the compatibility of film formers, plasticizers, masking technologies, and APIs to achieve the characteristics of the desired non-disintegrating buccal film properties.

Preparation Method Screening

We focus on the performance testing and safety evaluation of buccal film. We select the appropriate casting technology based on the properties and characteristics of the non-disintegrating buccal film. At the same time, we also analyze many aspects to ensure the applicability of the method.

Quality Control

Our oral thin film technology platform is equipped with the world's top brands of equipment, including an X-ray powder diffractometer, Raman spectrometer, thermogravimetric differential thermal meter, gas adsorption detector, texture meter, rheometer, high-performance liquid chromatography, vacuum emulsion tank, electrostatic spinning machine, coating machine, and scutter, etc., in the entire development and production process to implement strict quality control.

Manufacture

In the whole process of pilot development, pilot scale, and commercial production of oral thin film preparations, we can realize all-round control of key process parameters of non-disintegrating buccal film.

Our Technologies for Non-Disintegrating Buccal Film Development

Our Advantages in Non-Disintegrating Buccal Film Development

• Customized Drug Release Profiles: Our non-disintegrating buccal film development services enable the customization of drug release profiles, allowing for precise modulation of therapeutic effects and ensuring consistent drug release, ensuring that the integrity of the drug remains unchanged over time.
• Excipient Screening Service: The non-disintegrating buccal film is flexible, it also shows the fragile, effervesced granule property, so our expert teams play special attention to the selection of plasticizers to ensure the flexibility of the buccal film and prevent brittleness.
• Professional Taste Masking Technology: Taste masking is a necessary condition for the commercial success of non-disintegrating buccal film. We have professional taste mask technical teams, our technical teams can microencapsulate drugs with unacceptable taste, such as bitterness into some pH-sensitive polymers through solvent evaporation and solvent extraction techniques. These polymer microspheres exhibit effective taste masking.
• Advanced Development Platform: We have an advanced and comprehensive non-disintegrating buccal film drug development platform to maximize experimental success.

Published Data

Relying on the advanced technology platform and professional research and development team, CD Formulation constantly overcomes difficulties and explores innovations to provide effective development solutions for non-disintegrating buccal film drug delivery systems. If you have any requirements about our non-disintegrating buccal film development services, please contact us by phone or email, our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.