Fourier Transform Infrared (FT-IR) Spectroscopy Analysis for Oral Thin Film
Inquiry
Fourier Transform Infrared (FT-IR) spectroscopy is an excellent analytical tool, that can rapidly determine important quality parameters. During formulation and development of oral thin film, FT-IR is used to measure and examine infrared spectra of all components entering oral thin film formulations to detect unwanted interactions between formulation components and the pure API and identify the spectrum of chemical ingredients present in the oral thin film sample. CD Formulation provides professional FT-IR analysis techniques to check the interactions between the active ingredients, and excipients, helping to develop high-quality oral thin films.
Fig.1 FTIR spectra of rizatriptan, Proloc, HPMC F4M, and drug-loaded buccal film (F1).
(Anroop B. Nair, et al., 2021)
What is FT-IR Analysis?
FT-IR analysis measures the infrared region of the electromagnetic radiation spectrum, which has a longer wavelength and a lower frequency than visible light. This spectrum is measurable in a sample when subjected to infrared radiation (IR). The basic theory is that the bonds between atoms absorb light at different frequencies. FT-IR analysis measures the range of wavelengths in the infrared region that are absorbed by a thin film sample. The sample's ability to absorb the infrared light's energy at various wavelengths is measured to determine the sample's molecular composition and structure.
The Importance of Oral Thin Film FT-IR Analysis
- Provide information on the molecular structure and interactions between the different components of the oral thin film.
- Identify the excipients used in the formulation of oral thin films, as well as detect any impurities or degradation products that may be present
- Confirm the presence of the desired API in the oral thin film formulation, ensuring the correct API is delivered in the intended dose.
Our Oral Thin Film FT-IR Analysis Services
As a leader in the oral thin film industry, CD Formulation offers comprehensive FT-IR analysis for oral thin film, including:
- Identify and quantify the active pharmaceutical ingredients
- API - Excipient Compatibility Studies
Evaluate the compatibility of excipient-API and between excipients to provide the basis for formulation development.
- Detection of Excipients and Impurities
Our FT-IR analysis helps customers obtain excipient composition and impurities, which assists in the formulation development of oral thin films.
- Our FT-IR analysis can help study molecular structure and interactions within oral thin film formulations, etc.
Our Workflow of Oral Thin Film FT-IR Analysis
Our dedicated team of experts utilizes state-of-the-art FT-IR instrumentation and techniques to deliver accurate and reliable results that can help our clients optimize oral thin film formulations. Our service process is as follows:
Fig.2 Process of Oral Thin Film FT-IR Analysis Services. (CD Formulation)
Our Oral Thin Film FT-IR Analysis Capabilities
| FT-IR Analysis |
Detailed Information |
| FT-IR Spectroscopy Techniques |
FT-IR spectroscopy is a widely used analytical technique for studying the chemical composition of materials based on their molecular vibrations. This instrument typically consists of an infrared source, interferometer, detector, and data system. The spectrometer generates an infrared spectrum by measuring the absorption or transmission of infrared radiation by the sample. |
Advantages of Our Oral Thin Film FT-IR Analysis
- Expertise and Experience: Our team of experienced analysts and scientists have extensive experience in FT-IR spectroscopy and the analysis of oral thin films.
- Customized Analytical Solutions: We offer customized analytical solutions tailored to the specific needs and requirements of our clients. Whether you need the identification of active pharmaceutical ingredients, detection of impurities, or stability studies, we can tailor our FT-IR analysis services to meet our clients' objectives.
Published Data
Technology: FTIR studies
Journal: Asian J Pharm Clin Res
IF: 10.7
Published: 2012
Results: In this study, the compatibility of drugs and polymers was studied using Fourier Transform Infrared (FT-IR) spectroscopy. FT-IR Spectrum was recorded between 600-4000 cm-1. The results show that the FTIR spectrum of montelukast depicts a characteristic absorption band at 3437 cm-1 representing the presence of the OH group. The CH2 and C-N vibrations showed a characteristic absorption band in the region of 2926 cm-1 and 1265 cm-1. The spectrum of montelukast-polymer physical mixtures showed absorption bands at 3414 cm-1, 2926 cm-1, and 1266 cm-1 OH, The CH2 and C-N. It indicates drugs and drug-containing physical mixture absorption bands were near and that there was no chemical and physical change in the functional groups present in montelukast sodium.
Fig.3 FTIR spectra of a) montelukast sodium, b) hpmc e 50 lv, c) hpmc e 15 lv, d)
physical mixture of polymers and montelukast sodium (K. VIJAYA SRI, et al., 2012)
CD Formulation is committed to providing high-quality oral thin film FT-IR analysis services, we have professional FTIR analysis knowledge, rich experience, advanced instruments, and customized solutions. If you require our oral thin film FT-IR analysis services, please contact us by phone or email, and our colleagues will get back to you within three working days.
References
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Anroop B. Nair, Jigar Shah, et al. Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation. 2021, 13(5):728.
- K. VIJAYA SRI, P. ROHINI, et al. MONTELUKAST SODIUM ORAL THIN FILMS: FORMULATION AND INVITRO EVALUATION. Asian J Pharm Clin Res. 2012, Vol(5):266-270.
How It Works
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STEP 3
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