Disintegrant Screening of Oral Thin Film

As a new preparation, the oral thin film can quickly disintegrate and release drugs in the mouth without the need for water delivery. It has the advantages of fast dissolution and is easy to take. Disintegrant is the key factor in achieving the rapid disintegrant effect of oral thin film. CD Formulation provides disintegrant screening service based on the preparation method of oral thin film and the properties of active pharmaceutical ingredients (APIs).

Why Use Disintegrants in Oral Thin Film?

The FDA recommends that the dissolution time of oral thin film in the mouth should be less than 30s, and the use of disintegrants can accelerate the disintegration of oral dissolved film in the mouth.

Types and Peculiarity of Disintegrant for Oral Thin Film

Our Disintegrant Screening for Oral Thin Film Development

CD Formulation based on the preparation process and API properties of oral thin film comprehensively evaluates and screens the most suitable disintegrant from the following aspects to ensure the quality and efficacy of oral thin films and achieve good therapeutic effects:

Drug Content Determination

Oral thin films have high porosity and can disintegrate and dissolve rapidly in the oral cavity. The surface area of the drug increases with the disintegration of the thin film, and the dissolution rate is accelerated to form a drug solution. We usually use content determination as an important index for the disintegrant screening of the thin film.

Folding Endurance and Tensile Strength

The oral thin film should have good folding endurance and tensile strength, and will not be easily broken during use.

Friability

Disintegrants used in oral thin films should be non-toxic, non-irritating free of impurities, readily available, and relatively inexpensive. In addition, the obtained thin film should also be strong enough to avoid any physical damage during handling or transportation.

In Vitro Determination of Disintegration Time

The disintegration time is a key indicator in the development of oral thin film. Different preparation processes use different disintegrants, and the properties of APIs will also affect the choice of disintegrants.

Fig.1 Schematic diagram of devices to determine the disintegration behavior of the oral soluble films. (Di Gao, et al., 2023)

Our Platforms for Disintegrant Screening of Oral Thin Film

Advantages of Our Disintegrant Screening Services

• Efficient: We have an efficient screening process for disintegrants to speed up your oral thin film development.
• Experience: We have a professional accessories selection team, and they are familiar with the properties of various raw materials and excipients and can adjust the disintegrant at any time according to the preparation process of oral thin films.
• Reliable Partners: We are also a reliable manufacturer of excipients, serving the pharmaceutical industry to help it improve the performance of its products.

Published Data

CD Formulation can provide the most professional disintegrant screening technical guidance for customers. If you have a requirement about our disintegrant screening of oral thin film services, please contact us by phone or email, and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.