CD Formulation has a professional pharmacodynamic evaluation team. With years of experience, we have developed a comprehensive pharmacodynamic research platform. This platform enables us to conduct cellular pharmacokinetic studies and in vivo pharmacodynamic studies in various disease models based on customer requirements. We aim to assist in understanding the mechanisms of pharmacodynamic effects and conducting clinical translational research.
Pharmacodynamic evaluation is a crucial step in the process of developing new drugs. By comprehensively assessing the therapeutic effects, mechanism of action, efficacy-dosage relationship, and safety of a drug in in vitro cellular and in vivo animal models, the therapeutic potential of a drug can be confirmed, optimal dosing regimen can be established, safety can be evaluated, and a solid scientific foundation can be provided for the design and implementation of subsequent clinical trials. Nucleic acid pharmacodynamic evaluation can encompass the primary pharmacodynamic studies of anti-inflammatory immunity, anti-tumor, cardiovascular system, respiratory system, metabolic diseases, and other drugs. This helps meet the requirements of in vivo experiments, mechanism exploration, and molecular biology research at various research levels, thereby elucidating the efficacy and safety of new drugs.
CD Formulation offers a full range of drug discovery and pharmacodynamic evaluation services for nucleic acid drug discovery with a high level of technical expertise. We are committed to providing our clients with comprehensive services at competitive quality, lead times, and market prices to accelerate your scientific research. Customers can choose to combine our services according to their own needs.
In vivo activity is the gold standard for evaluating a drug's biological activity and serves as the initial non-human validation of integrated activity. Assessing drug efficacy in vivo is crucial in new drug discovery and development, as it significantly contributes to identifying candidate molecules and screening clinical target indications. We also offer drug efficacy evaluation for assisted reproduction drugs to cater to various new drug development projects and provide customized services as needed.
Fig.1 Different disease models.(CD Formulation)
We also offer in vitro drug efficacy testing services for various types of drugs, such as nucleic acid and protein assays, cell autophagy assays, cell proliferation assays, apoptosis assays, cell motility assays, and other experiments or tests. A detailed list of testing items is provided in the table below.
Category | Test Items |
---|---|
Nucleic Acid and Protein Assay |
|
Cellular Autophagy Assay |
|
Cell Proliferation Assay |
|
Apoptosis Detection |
|
Cell Motility Assay |
|
Other Assays |
|
Fig.2 Platforms for nucleic acid pharmacodynamic evaluation.(CD Formulation)
Technology: Pharmacodynamic evaluation of anticoagulants developed using RNA aptamer technology
Journal: Circulation
IF: 35.5
Published: 2006
Results:
The authors evaluated in healthy volunteers a novel anticoagulation system (REG1, Regado Biosciences, Inc.) that employs an oligonucleotide bound to the factor IXa protein (drug, RB006) and its complementary oligonucleotide antidote (RB007). In this first-in-human trial, the primary objective was to characterize their safety and pharmacodynamic response. The results of this experiment represent the first human trial of an RNA analog and its complementary oligonucleotide antidote for use as an anticoagulant system. These findings contribute to an emerging platform of selective, actively reversible anticoagulants for patients with thrombophilic diseases of the venous and arterial circulation.
Fig. 3 Pharmacodynamic effects of RB006 at 0 to 3 hours after RB006 administration. (Dyke C K, et al., 2006)
CD Formulation's specialized technical team has extensive experience in studying the efficacy of nucleic acid drugs, ensuring that your research projects run smoothly and efficiently while saving money and speeding up the drug discovery process. Contact us for a customized solution.
Reference