Metabolite Identification for Nucleic Acid Drugs

Metabolite identification plays a key role in drug discovery, preclinical development, and clinical development. CD Formulation's scientists conduct metabolite identification studies to identify and confirm metabolic sites and corresponding structural parts. This information greatly improves the validity of metabolic stability assays and facilitates the selection of the next series of compounds.

Why Metabolite Identification of Nucleic Acid Drugs?

Nucleic acid drug metabolism research is the material basis for elucidating drug safety and efficacy, and it is also the core and difficulty of drug metabolism research, which is often challenged by missing metabolites and false positives. A comprehensive understanding of drug metabolism pathways requires a large investment of resources, including technical staff, analytical equipment and time. During drug development, metabolic stability assays can provide insights into the metabolic process, kinetic properties, and pharmacological activity and toxicity of metabolites in vivo, which can provide a key basis for subsequent dosage design, optimization of dosing regimens, interpretation of species differences, and screening and optimization of new drug candidates, thus ensuring the safety and efficacy of the drug, and ultimately contributing to the successful development of novel nucleic acid drugs.

Fig.1 Metabolism attributes studied in early drug discovery. (Prasad B, et al., 2011)

Explore Our Nucleic Acid Drugs Metabolite Analysis Services

CD Formulation offers comprehensive metabolite analysis and structure characterization services for the analysis, isolation and characterization of metabolites in biological matrices to support drug discovery and safety studies. Our team of scientists can custom design experiments to address challenging metabolic research questions and work with research centers and departments across the company to resolve issues in a timely and efficient manner. We ensure timely delivery of reports that meet the requirements of relevant regulatory authorities. Our flexible and customized metabolite analysis and characterization solutions are designed to meet the needs of our clients.

Our services include the following.

In Vitro Metabolite Characterization

• Metabolic soft spot analysis for compound structure optimization.
• Reactive metabolite screening for compound structure optimization.
• Evaluation of major metabolites in vitro and comparison of species differences, selection of toxicological species.

In Vivo Metabolite Identification

• Evaluation of metabolites and metabolic clearance pathways in the circulatory system of animals/human body.
• Evaluate the safety of metabolites and assess the appropriateness of selecting toxicological species.

Radioisotope Tracer Metabolite Identification

• In vitro identification of metabolites and comparison of species differences by radioisotope tracing techniques.
• Evaluation of metabolites and metabolic clearance pathways in the circulatory system of animals by radioisotope tracer techniques.

Our Technology Platforms for Nucleic Acid Drugs Metabolite Analysis

Our technology platform enables bioscientists to characterize metabolites in drug discovery and drug development settings.

Why Choose Us for Nucleic Acid Drugs Metabolite Analysis?

• We can systematically identify various types of metabolites, including oxidized metabolites, hydrolyzed metabolites, phosphorylated metabolites, etc., and comprehensively evaluate the metabolic process of drugs in the body.
• Using advanced analytical techniques such as high-resolution mass spectrometry (HRMS), we are able to detect and characterize trace metabolites, which helps to obtain more accurate metabolic kinetic data.
• The establishment of quantitative analysis methods for key metabolites can realize the quantitative study of metabolism and provide data support for pharmacokinetic modeling and prediction.
• Through the identification of metabolic enzymes and pathways, the metabolic mechanism of nucleic acid drugs can be understood in depth, which can provide a basis for further optimization of drug design.
• We provide one-stop metabolite identification service from experimental design, sample preparation, analysis and testing to data interpretation to improve work efficiency.

Publication Data

CD Formulation provides reliable, rapid and cost-effective metabolite identification service for nucleic acid drugs, which can realize qualitative and quantitative identification of a variety of metabolites. All you need to do is inform us of your experimental objectives and send us your samples. We will handle all subsequent aspects of the project, including sample collection, metabolite extraction, and bioinformatics analysis. If you are interested in our services, feel free to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.