Transdermal Drug Delivery System Development

Why You Need to Develop an Innovative Transdermal Drug Delivery System?

Transdermal drug delivery systems (TDDS) have become an interesting research topic in the field of pharmaceutical technology and are one of the most commonly developed pharmaceutical products by pharmaceutical companies. Its core concept is to gradually release drugs into the blood through the skin to achieve therapeutic goals. The use of these systems can overcome the disadvantages associated with other delivery routes (e.g., oral and parenteral), including achieving long-term and stable release of drugs, avoiding drug degradation and digestion in the digestive tract, and reducing the first-pass effect of the liver.  However, traditional transdermal formulations suffer from poor efficacy due to multiple factors such as the presence of skin barriers and drug solubility. To address some of the limitations of traditional formulations, there is an urgent need to develop innovative transdermal drug delivery systems to meet the needs of pharmaceutical companies.

Fig. 1. Summary of the technologies utilised for enhancing transdermal drug delivery. (Ramadon D, et al., 2022)

Explore Our Transdermal Drug Delivery System Development Services

CD Formulation specializes in the development of innovative transdermal drug delivery systems, offering a range of services to assist pharmaceutical companies in bringing their products to market. Our goal is to support pharmaceutical companies in the development and commercialization of transdermal drug delivery systems, helping to bring innovative new treatments to patients in need.

Our services include but are not limited to:

• Formulation development
• Drug feasibility studies
• Delivery system design
• Analytical testing
• Scale-up and manufacturing

What Transdermal Drug Delivery System Can We Develop?

• Transdermal Patches

Transdermal patches are preparations the drug is dispersed in a hydrophilic or hydrophobic matrix and loaded onto a backing layer that adheres to the skin.

• Membrane-controlled transdermal patches, drugs and penetration enhancers are wrapped in a reservoir formed by a controlled-release membrane or other controlled-release materials, and the release of the drug is controlled by the controlled-release membrane or controlled-release materials.
• Matrix diffusion-controlled transdermal patches, the drug is evenly dispersed in the matrix, and the matrix controls the release of the drug.

• Semi-solid Dosage Forms

Semi-solid dosage forms, a semi-solid state or a semi-solid-liquid mixture, usually exist in the form of gels, ointments, patches, suppositories, etc., and consist of one or more active ingredients dissolved or evenly dispersed in a suitable matrix and any suitable excipients. Our semi-solid formulation development capabilities include, but are not limited to:

• Hydrogel.
• Non-hydrogel.
• Organogel.
• Thermosensitive gel.
• pH-sensitive gel.
• Cream/lotion dosage form (water-in-oil (W/O) or oil-in-water (O/W)).
• Ointment dosage form.

Our Innovative Technology for Transdermal Drug Delivery System Development

• Transdermal delivery technology. Specialized in using microneedle patches and ion delivery to develop new types of delivery that can penetrate the skin and deliver drugs to deep tissues, achieving higher delivery efficiency and faster drug onset time.
• Controlled release technology. Focus on using nanotechnology or microcapsule and other technologies to encapsulate drugs, so that the drugs can be slowly released to the skin surface, ensuring the sustained and effective concentration of the drugs in the body, while reducing the frequent replenishment of drugs.
• Skin patch technology. We have developed a patch that fits the skin better, softer, and more comfortable, which can reduce local irritation and allergic reactions and improve the convenience and comfort of treatment.
• Intelligent control technology: Real-time monitoring and regulation of drug concentration in the body is achieved through sensors, smart chips, and other technologies, thereby enabling personalized control of the dosage, improving therapeutic effects and reducing adverse reactions

Why Choose CD Formulation for Transdermal Drug Delivery System Development?

• Flexible customization strategy, we can develop personalized solutions according to the characteristics and needs of customers' drugs, including drug analysis, preparation development, quality control, production technology, etc.
• End-to-end solution, from early formulation development to critical trials and product launch.
• Supporting analytical service support enables comprehensive characterization of formulations, including physical and chemical characterization, biological characterization, stability studies and skin penetration studies.
• Guided by customer needs, we communicate with customers in a timely manner at each project stage to make adjustments and improvements to ensure timely and efficient delivery.

CD Formulation is at the forefront of the development of innovative drug delivery systems, providing customized solutions for transdermal drug delivery systems. Our expertise lies in utilizing advanced technologies and techniques to design safe, efficient, and reliable transdermal drug delivery systems that effectively deliver drugs through the skin and into the bloodstream. Please contact us today to learn more about our customized solutions for transdermal drug delivery system formulations.