On the basis of years of research and development (R&D) experience, the CD Formulation R&D team has established a complete sustained-release oral solid preparation platform and is committed to creating professional, quality-controllable sustained-release pellets, gastric retention tablets, gel matrix tablets, enteric-coated tablets, double-layer tablets, enteric-coated tablets, osmotic pump tablets, etc., to meet different customer needs.
Sustained-release oral preparations refer to preparations that can sustainably release drugs for a long period of time after administration to achieve long-lasting effects. Its characteristic is that the drug is slowly released into the body at a certain rate, mainly a first-order rate process, thereby maintaining the concentration of the drug in the blood at a certain level and prolonging the duration of the drug effect. Controlled-release oral preparations refer to preparations that can automatically release drugs at a predetermined rate within a predetermined time so that the blood drug concentration can be maintained within the effective concentration range for a long time.
According to the structure and composition of the drug delivery system, sustained and controlled release oral solid preparations are mainly divided into:
As an expert in technology-based innovative drug delivery systems, CD Formulation is committed to the development and engineering research of novel oral sustained-release formulations.
We have innovated and improved surface area-controlled sustained-release technology, matrix sustained-release technology, double-layer sustained-release technology, ion exchange resin controlled release technology, inclusion compound coating technology, osmotic pump controlled release technology, sustained-release capsule technology, and other sustained and controlled release technology platforms.
Our scientists are proficient in various process development and engineering production technologies for various new sustained-release and controlled-release preparations, including aqueous dispersion-coated sustained-release pellets, extrusion-spheronization-airflow-coated sustained-release pellets, matrix tablets, gastro retention tablets, osmotic pump tablets, sustained-release pellets/pellets, pulse release agents, and enteric coating tablets.
| Technology platform | Methods |
|---|---|
| Skeleton material sustained release technology | Our scientists have developed a sustained-release preparation based on aqueous gel, which achieves long-term release through the dissolution of different sustained-release materials. Available hydrogel excipients include cellulose, polymers, and resins.
|
| Micropellet technology | Solid pellets that dissolve and disperse drugs in a spherical or quasi-spherical skeleton or adsorbed on the skeleton. We can make immediate-release pellets, sustained-release pellets, and controlled-release pellets according to different medication needs. |
| Membrane control technology | Our membrane-controlled technology uses drug-containing granules/pellets as the smallest unit for drug release and uses water-soluble or pH-dependent sustained-release materials as coating films to achieve sustained-release or intestinal-release preparations. Sustained/controlled film materials: ethyl cellulose, methylcellulose, hydroxypropyl cellulose, cellulose acetate and its derivatives, ethylene-vinyl acetate copolymer, etc. |
| Solubilization technology | Our solubilization technology mainly uses solid dispersion solubilization technology (hot melt extrusion, spray drying, hot melt spray, etc.) to improve solubility. |
| Osmotic pump technology | Our osmotic pump technology is made by utilizing the osmotic pump principle and laser technology to release drugs at a uniform and constant rate with zero-order kinetics, thus being immune to the influence of physiological variables such as gastrointestinal motility and media environment pH. This helps maintain stable drug plasma concentrations, reduce drug side effects and dosing frequency, and improve drug safety and effectiveness. |
| Immediate release-sustained release combined technology | We have developed a unit preparation that contains immediate-release granules (or pellets) and sustained-release granules (or pellets) to achieve a combination of fast and slow drug release. |
| Colonic drug delivery technology | The drug can be released at the rear end of the digestive tract by using a new polymer resin material, which can reduce gastric irritation, local drug accumulation, and targeted drug delivery. |
| Gastrointestinal targeting technology | The drug can be retained in the corresponding gastrointestinal tract by fully understanding the solubility of different enteric materials at different pH values, playing a role in the targeted delivery of the gastrointestinal tract. |
In order to support the development of a variety of sustained-release oral solid dosage forms, our innovative sustained-release dosage platform is equipped with first-class equipment and testing instruments, including but not limited to:
CD Formulation has always been at the forefront of the development of innovative drug delivery systems. Thanks to our advanced sustained/controlled release oral solid formulation platform, we provide oral sustained and controlled release formulation development and production services to customers around the world. If you are interested in our services, please contact us today.
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