Semi-Solid Formulation Development

Advantages of Solid Dosage Forms

Semi-solid dosage forms, a semi-solid state or a semi-solid-liquid mixture, account for a large part of pharmaceutical preparations. These preparations usually exist in the form of gels, ointments, patches, suppositories, etc., and consist of one or more active ingredients dissolved or evenly dispersed in a suitable matrix and any suitable excipients, and have good adhesion and viscosity. Semi-solid formulations are usually absorbed through the skin or mucous membranes and have the following advantages:

• Easy to use.
• Quick preparation.
• Topical delivery.
• Avoid intestinal and hepatic first-pass effects.
• High patient compliance.
• Reduce the likelihood of side effects.
• intestinal and hepatic first-pass effect.

Explore Our Semi-Solid Formulation Development Services

Thanks to our liquid/semi-solid formulation platform, CD Formulation can easily handle a wide range of pharmaceuticals. Whether you want to develop a cream for dermal application, a gel, a transdermal patch, or a suppository for mucosal delivery, our scientists can confidently design a formulation to fit your needs.

• For new chemical entities, we use comprehensive drug formulations to evaluate their physicochemical properties and optimize their bioavailability.
• For the optimization of existing formulas, we can improve the stability, solubility, and transdermal delivery performance of the drug by adjusting the proportion of ingredients and changing the formulation process.

Our expert team not only focuses on the development of conventional semi-solid formulations but is also constantly exploring innovative technologies to meet changing market needs and consumer preferences.

Our semi-solid formulation form development services include, but are not limited to:

General Workflow of Our Semi-solid Formulation Development Services

• Our expert team communicates with you to clarify the drug types of semi-solid preparations such as ointments, gels, emulsions, etc.
• Screening of pharmaceutical bases: Based on the nature of the drug and the needs of the target market, screen the pharmaceutical bases that suit your dosage form, such as gelatin, glycerin, carboxymethylcellulose sodium, etc.
• Excipient screening, which includes studying the relationship between active pharmaceutical ingredients and excipients, and screening the best auxiliary ingredients, such as moisturizers, emulsifiers, thickeners, etc.
• Formula design: Based on the properties of the drug and the requirements of the target dosage form, we design a suitable formula and conduct preliminary tests.
• Preliminary experiments: Conduct preliminary experiments on a laboratory scale and examine the rheology, stability, drug release, and other indicators of the semi-solid preparation.
• Optimize the formula: Based on the preliminary test results adjust the proportion of medicinal base and excipients, and conduct the experiment again to optimize the formula.
• Pilot production: Semi-solid formulations are prepared on a pilot scale and more rigorous experiments are conducted to evaluate their efficacy and stability.

Innovative Technology

• Liposome technology: Using liposomes as drug carriers to increase the solubility and stability of drugs in semi-solid preparations and improve the bioavailability of drugs.
• Polymer technology: The viscosity, adhesion, absorbency and other characteristics of semi-solid preparations can be adjusted to improve the release rate and stability of the drug through appropriate polymer materials.
• Ion gel technology: Stabilizes the drug content and release rate of semi-solid preparations by utilizing the network structure formed between solid and liquid by ion gel.
• Nanotechnology: Nanonizing drug particles to improve drug solubility and bioavailability while making semi-solid preparations easier to prepare and stable.
• 3D printing technology: 3D printing technology can be used to precisely control the release rate and dosage of drugs in semi-solid preparations to meet individualized treatment needs.
• Microcapsule technology: The drug is wrapped in tiny capsules, and the release rate and stability of the drug are controlled by regulating the size and structure of the microcapsules.

Why Choose CD Formulation for Semi-Solid Formulation?

• Extensive expertise in the development of semi-solid dosage forms.
• The ability to flexibly customize the release curve for improving existing formulas, thus meeting specific treatment requirements.
• End-to-end services, from pre-formulation research to clinical trial drug production.
• Reliable and high-quality manufacturing processes, ensuring consistency and reproducibility in formulation development.
• Regulatory expertise for navigating the complex landscape of drug development and ensuring compliance with all relevant guidelines and regulations.

CD Formulation is committed to continuous innovation and continuous improvement of liquid/semi-solid formulation technology platforms to ensure that our semi-solid formulations remain at the forefront of drug development. If you have any semi-solid formulation development needs, please contact us immediately. We guarantee to provide the highest quality services and the most advanced technical solutions to pave the way for your project.