Oral Liquid Formulation Development

When is It Necessary to Develop an Oral Liquid Formulation?

Oral liquid formulation is a pharmaceutical preparation that is given to patients in liquid form orally. Compared with other preparations, oral liquid formulations are more suitable for patients who have difficulty swallowing tablets or capsules, which are commonly used in the elderly and pediatric patients. In addition, since there is no solvent time limit, it has a faster onset of action and is often used in the digestive system, respiratory system, and pain relief. Liquid dosage forms for oral administration usually consist of true solutions, suspensions of small solid particles in fluids, and different types of emulsions (microemulsions, nanoemulsions). In addition, some inert ingredients are needed to increase stability (e.g., emulsifiers, thickeners, co-solvents, suspending agents, etc.), improve taste and appearance (e.g., flavoring agents and pigments), prevent deterioration (preservatives) and improve bioavailability.

Explore Our Oral Liquid Formulation Development Services

CD Formulation has rich experience in the formulation development of oral liquid preparations. We are committed to solving the dissolution and stability problems of some drug molecules with special properties for our customers. Our team of experts can adjust the ingredient ratios and process parameters in the formulation according to the specific needs of our customers to ensure that drug molecules are effectively dissolved and stable in oral liquids.

Importantly, our expertise allows us to develop taste-masking solutions for bitter APIs.

The types of oral liquid formulation we can develop include but are not limited to:

• Solution
• Ready-to-use and powder suspensions
• Emulsion
• Microemulsion
• Nano-emulsions
• Flavouring and taste masking solutions.
• Syrups
• Powder for reconstitution and/or suspension

Our Expertise for Oral Liquid Formulation Development

• Selection and characterization of excipients.
• Optimize API solubility and bioavailability.
• Study the interrelationships between API, excipients, and formulations, including viscosity, taste, odor, pH, and antimicrobial efficacy.
• Development and validation of analytical methods.
• Phychemical characterization, including appearance and color, pH value, properties, drug content, solubility, particle size, potential, stability, and bioavailability.

Innovative Technology

• Microencapsulation technology: Technology that encapsulates active ingredients in protective shells, which can improve the stability and bioavailability of suspensions. The release of active ingredients from suspensions can also be controlled.
• Nanotechnology

• Based on cholesterol-phospholipid nanoemulsions encapsulate poorly water-soluble drugs in an oil phase to improve bioavailability using very small amounts of organic solvents and surfactants to enhance efficacy.
• Polymer-based nanotechnology can encapsulate drugs in polymer mechanisms to enhance drug stability.

• Microemulsification technology: The oil phase and water phase are evenly mixed to form a stable microemulsion through high-pressure homogenization, microwave radiation, ultrasonic radiation, and other technologies.
• Emulsification technology: Drugs with poor water are made wettability into emulsions to improve the stability and solubility of the drugs and increase the bioavailability of oral liquid preparations.
• Solid dispersion technology: Disperse solid particles into the liquid phase through mechanical, chemical, or physical methods to form a uniformly dispersed liquid-solid mixture to increase the bioavailability and efficacy of oral liquid preparations. Common techniques include ball mill grinding, co-precipitation-vacuum drying, solvent-spray drying, and anti-solvent co-precipitation.
• High-shear mixing: High-shear mixing equipment is used to disperse and homogenize the ingredients in the suspension to ensure uniform distribution of active ingredients, achieve the required particle size distribution, and prevent particle settlement.
• Composite technology: Combining a variety of technical means, such as Microemulsification technology, microencapsulation technology, nanotechnology, etc., to improve the stability, permeability, and release effect of active ingredients of emulsion.

Why Choose CD Formulation for Oral Liquid Formulation Development?

• Extensive expertise in the development of multiple oral liquid formulations, including solution,  microemulsion, nano-emulsions, ready-to-use and powder suspensions, etc.
• Excellent in developing and producing formulas for taste-masked oral solutions
• State-of-the-art facilities and equipment for the development and testing of oral liquid formulations.
• The combined use of multiple innovative technologies.
• Cost-effective solutions to help customers save time and money during the formulation development process.
• Understands the importance of timely delivery of formulations and strives to meet all deadlines to ensure customers can get their products to market as quickly as possible.
• The highest quality standards are followed to ensure that the oral liquid formulations developed comply with all laws and regulations.
• End-to-end services, from pre-formulation research to clinical trial drug production.

With our capabilities and expertise in oral liquid formulation, CD Formulation can help you overcome solubility and release challenges for APIs. Please contact us today to learn more about our services and how we can support your drug development needs.