Capsule & Granule Development

Advantages of Capsule

Capsules are a common oral solid dosage form and are popular due to their ease of manufacture compared to other dosage forms. Furthermore, any formulation can be used in capsules, whether powder, granules, pellets, semi-solid or liquid. Its advantages include

• Smooth and easy to swallow.
• Taste masking effect.
• Less excipients.
• Simplified formulation of different dosage strengths.
• Easy to store and transport.
• Consumer acceptance is higher compared to tablets.

Explore Our Capsule & Granule Development Services

CD Formulation is committed to continuous innovation research and development to provide customers with high-quality, efficient customized capsule solutions. We constantly optimize existing technologies and introduce new technologies to ensure that our products are always at the forefront of the industry.

At CD Formulation, our expert team uses a variety of innovative technologies to produce capsules, including but not limited to nanotechnology, microencapsulation technology, sustained release technology, etc., to meet the development needs of different drug properties. The combination of these innovative technologies makes the capsules more efficient and controllable in absorbing and releasing drugs, reducing drug dosage and frequency, and mitigating drug side effects. In addition, our expert team is also good at developing soft capsules using a variety of technologies, such as sol packaging technology and double-layer packaging technology, to enhance the stability and bioavailability of drugs.

The types of capsules we can develop include but are not limited to:

• Liquid filled capsules
• Capsules of API or API formulation
• Formulated capsules of powder mixture or granules
• Extended-release capsules containing beads or mini-tablets

Notably, our scientists can prepare microparticles or nanoparticles for filling into hard gelatin capsules or compressing into tablets.

Key Workflows for Our Capsule Development

• Characterization of physiochemical properties of API.
• Utilize various innovative technologies, including nanotechnology and microencapsulation technology, to develop fillers that meet packaging needs. This may include characterizing the performance of various excipients.
• Determine the optimal ratio and formula of active ingredients and fillers to ensure the required release speed and effect.
• Study the compatibility of drugs and capsule materials, determine the most suitable materials for capsule encapsulation, and design the capsule preparation process.
• Optimization of the preparation process, including selecting the best capsule preparation methods and equipment, establishing production process parameters, and ensuring the stability and repeatability of capsule preparation.
• Quality control and quality assessment, including testing and evaluation of capsule appearance, size, packaging integrity, solubility, release performance, etc., to ensure that capsules meet pharmacopeia standards and quality requirements.
• Bioavailability and bioequivalence studies, including in vitro and in vivo release performance evaluation, drug absorption, distribution, metabolism, and excretion studies ensure that capsules have good bioavailability and bioequivalence.
• Stability studies include long-term stability and accelerated stability evaluation to examine the stability performance of capsules under different conditions.

Our Encapsulation Technology

• Nano packaging
• Microencapsulation
• Liposomes
• Sol-gel
• Phase separation
• Cohesion
• Aggregation
• Precipitation
• Extrusion granulation
• Fluidized bed
• spray drying
• Spray cooling/condensation

What Problems Can Our Capsule Formulation Development Services Solve?

• Improving the bioavailability of poorly soluble drugs by utilizing suitable excipients and formulation techniques.
• Customizing capsule formulations to meet specific dosing requirements or patient preferences.
• Addressing stability issues and developing formulations with extended shelf life.
• Enhancing the efficacy and safety of drug compounds through optimized drug delivery systems.
• Developing specialized formulations for targeted drug delivery to specific tissues or organs.
• Reformulating existing drug products to improve patient compliance or address adverse effects.

CD Formulation specializes in developing various capsule formulations at an early stage to overcome bioavailability challenges. Our R&D team is also constantly exploring new capsule formulation technologies to improve the efficacy of drugs and reduce adverse reactions during treatment. Please contact us today if you are interested in our services.