Nanoparticle Concentration Testing Service

In the fields of biomedicine, such as viruses, liposomes, exosomes, and in the field of inorganic materials, such as graphene, nano-silicon, nano-calcium carbonate, and nano-metal particles, a large number of nano-scale particles require accurate particle size characterization and nanoparticle concentration detection. The application and development of nanoparticle concentration detection technology have a very positive effect on further research in biomedicine, material production, and other fields. CD Formulation has conducted in-depth research on nanoparticle concentration determination in nanoformulation characterization, which can assist customers in the development and clinical transformation of nanoformulations.

Our Nanoparticle Concentration Testing Methods

We have two types of nanoparticle concentration measurement equipment. One is a nanoparticle concentration analyzer based on optical principles, such as dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and other analyzers based on optical principles. The other one is based on electrical principles, such as resistive pulse sensing (RPS).

Dynamic Light Scattering (DLS)

The basic principle of dynamic light scattering measurement of nanoparticles is based on the Brownian motion of nanoparticles. Smaller particles move at a higher speed than larger particles. By measuring the speed of the particles, their hydrodynamic diameter can be determined. Dynamic light scattering particle size analyzers often not only include particle size measurement functions, but also integrate functions such as electrophoretic light scattering (measuring Zeta potential), molecular weight measurement, light transmittance measurement, particle concentration measurement, refractive index, etc.

Nanoparticle Tracking Analysis (NTA)

The principle of NTA is to irradiate a concentrated laser beam through a glass prism to a solution of suspended particles. The glass with a chromium-plated surface minimizes the background signal. Thus, the intensity of scattered light from each particle is detected, the Brownian motion of the nanoparticles in the solution is observed, and images are taken. By tracking and analyzing the Brownian motion of particles, the size of nanoparticles is calculated according to the Stokes-Einstein equation, and the concentration is obtained by the number of particles.

Resistive Pulse Sensing (RPS)

Resistive pulse sensing is a single-particle detection technology. When particles in the electrolyte pass through the small holes, the resistance between the electrodes changes instantaneously in a circuit designed with a constant current. This results in an instantaneous change in current, the amplitude of the generated electrical pulse is proportional to the particle size, and the number of pulses is proportional to the number of particles. This method can detect multiple information such as particle size, concentration, zeta potential, and shape of particles at one time, achieving multi-dimensional and all-round detection.

Our Workflow of Nanoparticle Concentration Testing

Our team can promptly address your nanoparticle concentration testing needs, and you can receive our expert test report by following just four simple steps.

Fig.1 Our workflow of nanoparticle concentration testing. (CD Formulation)

Why Choose Us to Test Nanoparticle Concentration?

• We have multiple nanoparticle concentration analyzers based on optical principles, such as dynamic light scattering (DLS), and nanoparticle tracking analysis (NTA), and the other one based on electrical principles, such as resistive pulse sensing (RPS).
• Through our long-term research, we have also used nanoparticle tracking analysis (NTA) to design and optimize nanoparticle-based drug delivery systems, such as their size, shape, surface charge, targeting capabilities, etc.
• Relying on our complete analysis and testing service management specifications, we have a relatively fast sample circulation cycle, and can quickly respond to your detailed requirements for nanoparticle concentration testing immediately.

Published Data

CD Formulation has extensive experience in developing and producing nanoformulations. They offer design solutions and analytical methods for characterizing and analyzing nanoformulations to meet quality and efficacy requirements. They provide top-notch solutions for determining nanoparticle concentration to pharmaceutical researchers. Additionally, they have made significant progress in characterizing emerging nanoparticles like exosomes, microvesicles, and nanobubbles using nanoparticle tracking analysis (NTA) technology. For more information on their services, interested parties are encouraged to contact us for further discussion.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.