Nanoformulation Surface Property Testing Service

Nanoformulations possess unique surface properties, and even slight differences in their preparation can significantly alter the absorption, tissue distribution, elimination, and other pharmacokinetic parameters of the main drug in the body. These changes ultimately affect the drug's effectiveness and safety. Therefore, accurate and reproducible detection methods are essential to characterize the surface properties of nanoformulations, ensuring quality consistency between production batches. CD Formulation offers surface property testing services to meet our customers' diverse quality requirements during nanoformulation development and quality control.

Why Test the Surface Properties of Nanoformulations?

The surface properties of nanoformulation include surface charge, specific surface area, coating and thickness, ligand and density, etc. The functional properties of some nanocarrier materials change as the size of the sample decreases and the surface chemistry of the material changes. Therefore, the surface property of nanoformulations must be considered during nanomedicine toxicity characterization.

• Surface charge: The surface charge of nanoformulations may affect its aggregation performance and stability, interaction with cells, and biodistribution.
• Surface area: Nanoparticles have a high surface area to volume ratio, and nanoparticles have a large interaction surface area per unit mass, making some otherwise inert particles (such as gold) reactive in the nanometer range.
• Coating or functional modification of the surface: Coating or functional modification of the surface of nanoformulations may improve their biocompatibility, increase circulation time in the body, and achieve targeted delivery.
• Surface hydrophobicity: The surface hydrophobicity of nanoparticles determines the interaction between nanoparticles and between nanoparticles and biomolecules. Therefore, the surface characteristics of nanoparticles have a great impact on their stability, blood circulation, biological distribution, targeting, etc.

Our Nanoformulation Surface Property Testing

Nanoparticles have different physicochemical properties, including charged surfaces, aggregation capabilities, the possibility to bind other groups to the surface, and controlled synthesis that facilitates the acquisition of specific shapes and sizes. These properties make nanoparticles more reactive than conventional particles in biological settings. We are good at testing the surface properties of nanoformulations and can provide our professional services to meet your nanoformulation development needs.

Surface Charge Testing

The surface potential depends on the particle size, composition and dispersion medium of nanoformulations. The surface charge of nanoformulations is generally evaluated based on zeta potential. The measured value of zeta potential depends on the measurement conditions, such as dispersion medium, ion concentration, pH and instrument parameters. We have researched surface charge of nanoformulation by selecting appropriate methods and media, such as phase analysis dynamic light scattering (PALS), electrophoretic light scattering (ELS) or adjustable resistive pulse sensing technology (Tunable resistive pulse sensing, TRPS), etc.

Surface Structure Analysis

With the support of our advanced instruments and equipment, we utilized appropriate characterization techniques to analyze the surface structure of nanoformulations, including X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectroscopy (EDS), Time-of-flight secondary ion mass spectrometry (TOF-SIMS), nuclear magnetic resonance (NMR), elemental analysis or high-performance liquid chromatography (HPLC), etc.

Characteristics of Degree of PEGylation on The Surface of Nanoparticles and Elemental Composition

Characteristics such as the degree of PEGylation on the surface of the nanoparticles and the elemental composition can be characterized using appropriate mass spectrometry or spectroscopic methods.

Why Choose Us to Test Surface Properties of Nanoformulations?

• Our technicians have rich experience in nanoformulation development and quality control and can quickly respond to and assess your detailed requirements for surface property testing of nanoformulations.
• We have multiple world-class instruments and equipment for surface property testing, including ELS, PALS, XPS, EDS, HPLC, etc.
• Our service process is quite simple, you only need to clarify the details of your project, such as experimental purpose, sample information, control limit requirements, laboratory data requirements, etc. We will provide you with our professional analysis solutions and competitive quotations as soon as possible to efficiently advance the project.

Published Data

As your most loyal partner, CD Formulation has world-class instruments and equipment a sophisticated R&D team, and extensive experience in researching surface property testing methods of nanoformulations. If you are interested in our surface property testing services, please kindly contact us for detailed communication.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.