Nanoformulation Molecular Weight Distribution Testing Service

The molecular weight distribution (MWD) of polymers impacts properties of nanomaterials like processability, mechanical strength, and morphological phase behavior. CD Formulation utilizes various techniques such as light scattering and gel permeation chromatography/size exclusion chromatography to assess the molecular weight distribution of nanomaterials. This helps in meeting diverse customer needs for nanoformulation development and quality control.

Why is Molecular Weight Distribution of Nanoformulation Important?

Molecular weight distribution refers to the ratio of the weight-average molecular weight to the number-average molecular weight of a polymer. This value indicates the distribution of molecules in polymers with different chain lengths. Molecular weight distribution is usually represented by a curve, where a narrow distribution means the molecular weights are similar, while a broader distribution indicates a wider range of molecular weights.

Molecular weight distribution is important in evaluating the physical and mechanical properties of polymers and their behavior during processing and manufacturing. The significance of studying molecular weight distribution of polymers:

• The molecular weight distribution of the polymer has a great impact on the physical and mechanical properties of the material.
• By measuring the molecular weight and distribution of polymers, the mechanism and kinetics of polymerization and degradation reactions can be understood.
• The properties of polymer solutions are not only dependent on molecular weight but also related to polydispersity.

Measuring the distribution of polymer molecular weights is crucial for comprehending the characteristics and structure of polymer materials. Hence, we prioritize assessing the molecular weight distribution during the advancement of nanoformulations to support the progress and clinical application of these formulations.

Fig.1 Molecular weight distribution of a polymer. (Jean-Marie Lehn. 2015)

Our Molecular Weight Distribution Testing Techniques for Nanoformulations

The molecular weight distribution can be assessed by calculating the weight-average molecular weight divided by the number-average molecular weight. CD Formulation investigates and studies various techniques for testing molecular weight distribution, such as light scattering, osmotic pressure, viscometry, and gel permeation chromatography/size exclusion chromatography (GPC/SEC).

Light Scattering

Light scattering occurs when polarizable particles are placed in the oscillating electric field of a light beam. Light scattering methods rely on light that loses energy due to absorption, conversion to heat, and scattering as it passes through a polymer solution to measure polymer molecular weight distribution.

Right-angle light scattering (RALS) involves measuring the scattering intensity at a 90°angle from the incident beam, offering a high signal-to-noise ratio and is ideal for small molecules.

Low-angle light scattering (LALS) measures scattering intensity at angles near 0° to minimize errors related to anisotropic scattering.

Multi-angle light scattering (MALS) combines measurements from various angles to estimate the scattering intensity at 0°and is effective for molecules of all sizes.

Osmometry

Osmometry was used to determine the number average of molecular weight.

Vapor pressure osmometry (VPO) method indirectly measures vapor pressure by measuring the temperature change of a polymer solution as it is diluted with solvent vapor and is generally suitable for polymers with Mn below 10,000-40,000 g/mol.

Membrane osmometry determines Mn by separating the solvent from the polymer solution via a semipermeable membrane firmly fixed between two chambers. Membrane osmometry can be used to determine Mn from approximately 20,000-30,000 g/mol and less than 500,000 g/mol.

Gel Permeation Chromatography /Size Exclusion Chromatography (GPC/SEC)

Gel permeation chromatography (GPC) is a form of size exclusion chromatography (SEC) primarily utilized for determining the molecular weight of polymer substances.

Apart from the above determination methods, we also can perform the MWD utilizing mass chromatography (MS) and polymer long-chain determination (PLD).

Why Choose Us to Test Nanoformulation Molecular Weight Distribution?

• We can offer polymer molecular weight distribution testing services using appropriate methods, such as light scattering, osmotic pressure, viscometry, GPC/SEC, MS, etc.
• We can also quickly respond to your polymer’s molecular weight distribution testing requirements and provide you with our professional proposal and test report to support your nanoformulation development.

Published Data

CD Formulation has a variety of precise analytical instruments and equipment and a team with rich experience to provide molecular weight distribution testing services to support your nanoformulation development and clinical transformation. If you are interested in our MDW testing services, please feel free to contact us for detailed communication.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.