Oral Liposome Formulation Development

At CD Formulation, our oral liposome research center is dedicated to assisting clients in overcoming various challenges in the development of oral liposomes. We have decades of experience in developing oral liposome projects, particularly focusing on maintaining liposome integrity, prolonging gastrointestinal residence time, and enhancing liposome stability. At present, our oral liposomes primarily target unstable molecules, such as proteins and many precursor drugs. Regardless of your goals of enhancing drug bioavailability, reducing drug side effects, enhancing drug stability, or addressing large-scale production challenges, we can offer the optimal solution for you. We aim to provide our customers with high-quality and efficient oral liposome formulations to meet the needs of various industries and application scenarios.

Why Develop Oral Liposome Formulations?

Liposomes exhibit promising potential as carriers for drugs and nutrients due to their high encapsulation capacity, biocompatibility, and safety profile. However, challenges in oral delivery arise from issues such as instability within the gastrointestinal tract, limited biofilm penetration ability, and difficulties in large-scale production. Strategies including adjusting formulation composition and implementing surface coating techniques have been explored to enhance liposome stability. By optimizing the lipid bilayer composition, drug solubility can be improved while maintaining optimal concentration levels in vivo. This facilitates absorption while minimizing interference from food intake and individual variations. Formulation development plays a crucial role in advancing the field of oral liposomes.

Our Oral Liposome Formulation Development Services

To address major challenges in the formulation of oral liposomes, we can provide you with the following services to improve the stability and absorption of liposomes to improve the efficiency of oral delivery of liposomes.

Formulation Optimization

The services we offer encompass various phases of oral lipid formulation development, ranging from laboratory-stage formula optimization to small-scale, pilot, and scale-up stages.

Phospholipid Functional Modification

In addition to traditional formulation development services, we also provide you with phospholipid functional modification services to improve the stability of liposomes. At the same time, we can also match your phospholipid system with different phase transition temperatures to meet your project needs.

Polymer Coatings Services

Based on our many years of research and development experience in the field of oral liposome formulation development, polymer coatings can protect the payload to varying extents, mainly by improving the adhesion to enhance the permeability of liposomes. We can offer polymer coatings services for liposomes including long-chain polyethylene glycol, chitosan, polysaccharide, protein, and its derivatives.

Ligand-mediated Services

We can provide ligand-mediated services that can also improve intestinal targeting, thereby improving the stability and bioavailability of oral liposomes.

Our Workflow of Oral Liposome Formulation Development

The formulation of liposomes is determined by the active ingredient, preparation method, type of phospholipid used, and intended application. The services provided by CD Formulation for oral liposome formulation development are primarily categorized into the following aspects:

• Formulation design: including screening of oil phase, aqueous phase, pH of aqueous phase, relevant ion concentration, drug-to-lipid ratio, etc.
• Process development: comparing preparation methods and optimizing process parameters.
• Liposome characterization: encapsulation efficiency, drug-loading rate, morphology and number of membrane layers, surface potential, particle size distribution, and stability analysis, etc.

Our Platforms for Oral Liposome Formulation Development

Our Advantages in Oral Liposome Formulation Development

• Advanced Technology. Unique platform and professional equipment.
• Expertise. Proven research portfolio solutions and expert teams in oral liposome development.
• Rigorous. The verifiable development methods are developed in accordance with the guidelines provided by ICH and IQ.
• Flexibility. The project design is collaboratively and customarily tailored, ensuring successful execution.

Applications of Oral Liposome Formulation

• Food and nutritional supplements: Liposomes enhance the stability, bioavailability, and targeted delivery of active ingredients in food and health products to augment their nutritional value, improve sensory attributes, and prolong shelf life.
• Pharmaceutical field: Liposomes are utilized for the development of unstable biomacromolecules or prodrugs in specific therapeutic areas such as cancer, gastrointestinal diseases, diabetes, cardiovascular diseases, and neurodegenerative diseases.
• Vaccines: Liposomes can serve as oral delivery vectors to elicit mucosal immune responses.

Published Data

Our scientists at CD Formulation are delighted to answer any questions you may have regarding the development of oral liposomes and provide consultation services for the development of your projects. If you are interested in our services or would like further communication, please feel free to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.