Liposome Vaccine Encapsulation Service

Liposomes have emerged as a critical adjuvant carrier system in vaccinology, celebrated for their multifunctionality and superior biocompatibility. Over the past decades, researchers have dedicated significant efforts to developing liposome-based vaccines to enhance efficacy and stability. CD Formulation leverages cutting-edge liposome encapsulation technology to assist enterprises and institutions in creating stable and efficient vaccine-encapsulated liposomes. Our expertise ensures high-quality, tailored systems that meet the unique demands of advanced vaccinology research.

Fig.1 The illustration of liposomes as adjuvants and vaccine delivery systems. (Schwendener RA, et al, 2014)

Importance of Liposome-Based Vaccine Encapsulation

Traditional vaccines do not require the use of adjuvants. They themselves contain antigens as well as additional components from bacteria or viruses that simultaneously effectively activate various elements of the innate immune system. Developing alternative strategies becomes more and more important as allergic and autoimmune reactions after vaccination, as well as the manufacturing and transporting challenges. Encapsulating antigens have these advantages:

• safeguarding antigens against premature degradation;
• enhancing uptake by antigen-presenting cells through passive or targeted transport;
• providing a reservoir for sustained antigen presentation;
• facilitating simultaneous delivery of antigens and adjuvants/immune stimulants to cells, thereby enabling modulation of the immune response type (humoral or cellular).

Fig.2 The mechanisms by which nanoparticles alter the induction of immune responses. (Schwendener RA, et al, 2014)

Overview of Our Liposome Vaccine Encapsulation Service

Antigen research services

Our research on vaccines includes viral vaccines, bacterial vaccines, genetically engineered vaccines, adjuvant vaccines, and innovative mRNA vaccines. Our liposome delivery service mainly focuses on genetically engineered vaccines and nucleic acid vaccines. We offer professional services for designing mRNA sequences and selecting nucleotide modifications for nucleic acid vaccines.

Formulation of vaccine-encapsulated liposomes

A significant advantage of liposomes as a vaccine delivery system is their inherent versatility and adaptability. By carefully screening the composition and preparation methods—including lipid composition, charge, size, electrostatic distribution, and the encapsulation or positioning of antigens or adjuvants—we can customize them to meet specific requirements. Water-soluble compounds (such as proteins, peptides, nucleic acids, carbohydrates, and semi-antigens) are generally encapsulated in the aqueous core, while lipophilic compounds (including lipid peptides, antigens, adjuvants, and linker molecules) are integrated into the lipid bilayer. Antigens can be affixed to the surface of liposomes through adsorption or stable chemical linkage.

Services for the development of vaccination pathways

Traditional vaccines are typically delivered via peripheral routes, and we remain dedicated to assisting our clients in exploring the potential of alternative administration routes. For instance, the contemporary approach of pulmonary vaccine delivery can be accomplished via nasal drops or by directly targeting the lung tissue.

Characterization service

To guarantee the efficacy of liposome vaccine design, we typically perform the following assessments: the expression levels of RNA coding, intracellular immunogenicity, the stability and toxicity associated with the chemical composition of the liposome vaccine, administration route, and therapeutic targets. Additionally, it is crucial to compare systemic administration of liposome vaccines with conventional intramuscular delivery methods.

Our Expertise in Liposome Vaccine Encapsulation

Why Choose CD Formulation?

Exceptional Technological Expertise in Liposome Vaccine-Encapsulated

• At CD Formulation, this technology is suitable for different vaccines, including DNA, RNA, and recombinant genes, showing broad application potential.
• We are actively exploring a range of innovative vaccination strategies like nasal administration.
• We are expertise not only in preventive vaccines but also therapeutic vaccines.

An Outstanding and Powerful Evaluation System

• A range of sophisticated instruments for liposome vaccine characterization, covering the entire process.
• The stability research platform supports precisely evaluating store conditions and offers verifiable data.
• The quality research platform is specifically designed for liposome vaccines to efficiently evaluate the characteristics of related liposomes in vivo and in vitro.
• We develop exclusive human in vitro models to precisely assess the immunogenicity and safety profiles of vaccines.

An Exceptionally and Esteemed Professional Team

• We have effectively supported enterprises and academic institutions in the research and development of liposome vaccines.
• Our technical team is comprised of a diverse array of scientists from various disciplines.

Published Data

CD Formulation specializes in providing advanced liposome encapsulation technology for vaccine development, including mRNA, DNA, and recombinant protein vaccines. Our solutions are tailored to meet the specific needs of enterprises and research institutions, ensuring reliable and innovative support for vaccine R&D. Contact us to explore how we can contribute to your projects.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.