Liposome Morphology/Structure Analysis
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Our liposome structure analysis team at CD Formulation, equipped with state-of-the-art analysis platforms and facilities, has earned the trust of numerous corporate and university partners over the years. The team is dedicated to continuous innovation and exploration, striving to advance liposome development across various fields. Moreover, we maintain a professional and diligent work ethic, ensuring exceptional quality for our customers' liposome products throughout the entire research and development process. If you are seeking an outstanding analysis supplier, we will be your utmost satisfaction.
Why Do You Need Analysis of Liposome Morphology/Structure?
Morphology distribution plays a crucial role in the performance of nanodrug systems, and liposomes are no exception. It determines the pharmacokinetics and biodistribution of drugs, while the drug morphology within liposomes significantly impacts their stability. In medical applications, morphological analysis is pivotal in determining drug circulation time, biodistribution, targeting efficiency towards diseased tissues, among others. For instance, elongated liposomes with enhanced fluidity exhibit reduced wall collisions and improved accessibility to blood vessels compared to spherical liposomes. Consequently, both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) mandate comprehensive and reliable analysis of this property.
What Can We Do About Liposome Morphology/Structure Analysis?
The morphological and structural analysis of liposomes holds significant guidance for the development of liposomes loading different effective components, as well as serving as a necessary step to evaluate the encapsulation effectiveness. The following professional services are available for our clients:
Real-time Analysis of Liposomes
In this service, we employ environmental scanning electron microscopy (ESEM) technology to investigate real-time morphological changes in liposomes, enabling the evaluation of lipid membrane and liposome suspension structure during dehydration for formulation and stability assessment. Additionally, TEM technology, confocal laser scanning microscopy (CLSM), flow cytometry, electrical impedance spectroscopy (EIS), as well as fluorescence technique can be utilized to observe and analyze the dynamic transformation process of liposomes, facilitating convenient in vitro and in vivo studies on their release kinetics.
Analysis of Liposome Internal Structure
Based on confocal laser scanning microscopy (CLSM) technology, we offer microscopic investigations of the internal mechanism of liposomes to cater to our clients' requirements for characterizing the morphology and structure of liposomes.
Study on Liposome Shape and Morphology
The utilization of atomic force microscopy (AFM) and transmission electron microscopy (TEM) is employed for the characterization of liposome shape, morphology, and the level of morphological regularity, thereby facilitating the investigation into liposome stability.
Study on Liposome Surface Characteristics
The atomic force microscopy technique (AFM) is utilized in this service to investigate the surface characteristics of liposomes, including surface roughness and viscosity.
Our Visualization Technologies for Liposome Morphology/Structure Analysis
Visualization analysis is a crucial and potent method for conducting morphological research, enabling visual imaging of complex biological systems at the molecular level. Our visualization platform offers a comprehensive and systematic analysis of liposome morphology and structure through diverse microscopic techniques, including size distribution, bilayer organization, vesicle shape, etc.
| Techniques & Platform |
Advantages |
| Transmission electron microscopy (TEM) |
- High resolution imaging.
- Available to evaluate the morphology and structure of liposomes.
- Convenience.
|
| Cryo-electron microscopy (cryo-EM) |
- Preventing sample moisture loss.
- The interference caused by NS-TEM can be mitigated.
- Suitable for water-based preparations.
|
| Atomic force microscopy (AFM) |
- Useable in a wet mode.
- Able to observe the morphology of liposomes without any sample handling.
- Feasible to investigate the surface characteristics of liposomes.
|
| Environmental scanning electron microscope (ESEM) |
- Ability to image liposomes in a naturally hydrated state.
- Ideal for real-time visualization of liposome formation and morphology.
- The sample environment is permitted to undergo changes during the testing process.
|
| Confocal laser scanning microscopy (CLSM) |
- The technique enables the acquisition of three-dimensional and high-resolution images in diverse environments, facilitating the investigation of liposome structures.
- A good method to study the deformability of liposomes.
- Suitable for analyzing the structure of liposomes with diameter less than 200nm.
|
Our Advantages in Liposome Morphology/Structure Analysis
- Fast and efficient. From the receipt of test samples to the delivery of analysis results, our team operates with exceptional speed and efficiency.
- Professional. The company boasts a team of seasoned professionals and an advanced analysis platform.
- Personality. The clients are provided with an exclusive project management team, dedicated to tailoring services according to their specific needs in order to ensure utmost customer satisfaction.
Published Data
Technology: Layer-by-layer self-assembled liposome technique
Journal: Food Hydrocolloids
IF: 19.3
Published: 2024
Results: In this study, the authors prepared layers of self-assembled liposomes with different mixing ratios of sodium alginate (SA) and chitosan (CS) (3:7, 1:1, 7:3), and studied their morphology and structure. It was proved that layer upon layer coated liposomes could achieve stable and efficient encapsulation of active ingredients, thus improving the bioavailability of bioactive substances.
Fig.1 Process of layer-by-layer self-assembled liposome development. (Xiangyun Tan, et al., 2024)
The liposome structural analysis team at CD Formulation has been providing services to clients across various industries for numerous years, facilitating advancements in liposome structural characterization analysis and garnering high acclaim. For further information, please do not hesitate to contact us.
References
- Xiangyun Tan, Yue Liu, et al. Layer-by-layer self-assembled liposomes prepared using sodium alginate and chitosan: Insights into vesicle characteristics and physicochemical stability. Food Hydrocolloids. 2024, Volume 149
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