Liposomes are wrapped with particles of various active ingredients, which can efficiently penetrate into the base layer of the skin, and absorb faster and better than ordinary skin care products. When used in basic skin care products, the effectiveness is naturally better than traditional skin care products. Due to its very small diameter, liposomes can easily penetrate the pores and the space between the stratum corneum cells, sending the active ingredients to the dermis and basal layer, allowing the skin to absorb more water and nutrients. The CD Formulation analysis center is capable of providing comprehensive, professional skin permeation and accumulation study. We provide in vivo analysis techniques such as tape stripping, microdialysis, vasoconstriction assay, spectroscopy, etc.

Why You Need Liposome Liposome In Vivo Skin Permeation and Accumulation Study?

If a drug can only penetrate the epidermis but not the dermis, it is referred to as topical administration, which is employed for the treatment of diseases such as skin cancer, psoriasis, eczema, and microbial infections since the root cause resides in the skin. If the drug has access to systemic circulation, it is known as a transdermal drug delivery system (TDDS), highly favored in biomedical fields and suitable for treating various conditions including depression, hypertension, angina, schizophrenia, and Alzheimer's disease. In vitro experiments offer advantages of simplicity, ease of implementation, and result reproducibility; however they fail to reflect effects related to skin blood flow and enzyme metabolism associated with actual cutaneous drug administration. Therefore, further development of transdermal drug delivery systems necessitates in vivo pharmacokinetic studies. In vivo pharmacokinetic experiments primarily investigate laws governing drug absorption,distribution ,metabolism,and excretion within an organism,and play an indispensable role in studying mechanisms of action and bioavailability.

Explore Our Services for Liposome In Vivo Skin Permeation and Accumulation Study

Plasma Sample Analysis Method Development

The dose of transdermal administration is generally small, and the drug cannot completely penetrate the skin with a multilayer biofilm structure, so the amount absorbed through the body is small, and the detection of blood drug concentration requires extremely high sensitivity. This is also the biggest challenge in skin testing plasma samples. To meet the requirements of extremely high sensitivity, on the LMS platform, our bioanalysis team comprehensively considers three aspects of mass spectrometry, liquid phase and sample pretreatment to improve the mass spectrum signal response of the compound.

Skin Tissue Sample Analysis

After skin samples are collected in vivo, our in vivo evaluation team has extensive experience in separating layers of skin tissue from frozen sections to meet the testing needs of our customers.

Analysis of stratum corneum samples

The cuticle is very thin and requires a special sample collection method. Tape stripping sampling method is widely accepted and used, and it is also the FDA recommended cuticle collection method. We have designed a unique set of pre-processing methods, such as ensuring maximum extraction of the analyte. Secondly, considering the cumbersome sample processing process, the working fluid of linear and quality control samples was directly added to the blank tape supernatant containing cuticle for subsequent analysis.

Our Platforms for Liposome In Vivo Skin Permeation and Accumulation Study

Highlights for Liposome In Vivo Skin Permeation and Accumulation Study

• Collections of multiple technologies. We have multiple technology platforms for in vivo skin permeation and accumulation study including tape stripping technique, spectroscopy technique, HSBA technique, etc.
• Team of experts. Our scientists have years of experience and expertise in in vivo skin permeation and accumulation study. Most of them come from prestigious universities and are researchers.
• Unique. We have a unique management model for in vivo skin permeation and accumulation study, implementing each client each project has a separate folder, from the raw data to the experimental plan to the final result report.

Published Data

CD Formulation has formulated a complete program of formulation optimization, drug administration, in vivo sample collection and quantitative analysis of biological samples from skin, which can efficiently complete experiments, provide accurate and reliable data, and facilitate the drug development process of skin administration. If you need any kind of assistance, please contact us immediately.