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Liposome Aerosol Formulation Development

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Liposome aerosol formulation.

Since its establishment, the Lipid Aerosol R&D Center at CD Formulation has been committed to professionalism, innovation, and efficiency in advancing the development of lung-targeted drug delivery systems. Our team comprises industry experts with extensive experience and a strong theoretical foundation. Leveraging state-of-the-art technology platforms, we consistently push ourselves to innovate and deliver bespoke services tailored to our customers' specific needs, aiming to address diverse challenges associated with liposome aerosol formulation development. Our objective is to deliver all-inclusive R&D services for liposome aerosols that enable clients to maintain a competitive edge in a fierce market environment and creating enhanced value for our esteemed clientele.

Why Develop Liposome Aerosol Formulations?

Liposome aerosols are typically administered as an aqueous solution but can also be given as dry powder. Nebulizers (such as metered dose inhalers and thousand powder inhalers) allow for the delivery of larger drug volumes while still enabling liposome preparation through traditional processes without additional procedures. Compared to parenteral administration, aerosol dosage forms provide an excellent means of direct lung administration. The safety of inhaled liposomes depends on the specific drug used and the amount delivered to the target site. Particle size and shape play crucial roles in determining lung deposition levels within the human respiratory tract. Minimizing liposome damage and preventing capsule rupture is crucial when using compressed gas to generate aerosols from aqueous solutions or suspensions. Additionally, compared with water-based solutions, dry powders can avoid liposome rupture but face challenges due to inherent instability during drying processes. In such cases, a good formulation becomes a key factor in liposome aerosol development.

Explore Our Liposome Aerosol Formulation Development Services

Our services encompass the entire R&D process of liposome aerosol, including formulation design, in vitro evaluation, testing phase, and challenges in mass production. Our professional team will provide tailored solutions based on customer requirements.

Formulation design

Starting from the initial formulation design, we will thoroughly consider the stability and bioavailability of liposome aerosol to ensure its efficacy in practical applications.

In vitro evaluation

During the in vitro evaluation phase, we will employ various advanced detection methods such as scanning electron microscopy and laser particle size analyzer to comprehensively analyze the morphology and particle size distribution of liposome aerosol, thereby offering robust support for product optimization.

Optimization of Formulas

In the mass production phase, our team will provide customers with expert technical assistance for any potential issues encountered during production processes to help them effectively overcome diverse challenges.

Our Workflow of Liposome Aerosol Formulation Development

Fig.1 Process of aerosol liposome formulation development.Fig.1 The workflow of liposome aerosol formulation development. (CD Formulation)

Our Platforms for Liposome Aerosol Formulation Development

Technology Platform Specific Contents
Formulation Development Preformulation and feasibility study, screening of formulation (i.e. the type of phospholipid and the concentration of cholesterol, has a great influence on the quality properties of the inhalation powder).
Nebulizer and Inhaler Technologies Platform Inhaler technology: dry powder inhaler, pressurized metered dose inhaler, soft mist inhaler and atomizer. Atomizer technology: air jet nebulizer (AJN), ultrasonic nebulizer (USN) and vibrating mesh nebulizer (VMN).
Stability Assessment Platform Physical, chemical, biological stability, package material compatibility assessment based on ICH. Measurement of aerosol deposition in airway model, aerodynamic size, oropharyngeal aerosol deposition, etc.
Instruments Liquid chromatography tandem mass spectrometry (LC-MS/MS), fourier infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), scanning electron microscope (SEM), transmission electron microscopy (TEM), DLS (dynamic laser light scattering), MALDI-TOF MS(matrix-assisted laser desorption ionization time-of-flight mass spectrometry), etc.

Our Advantages in Liposome Aerosol Formulation Development

  • Expertise. We have unique liposome preparation technology, which can produce various types of liposomes, including single-chamber liposomes, multi-chamber liposomes and nano-liposomes.
  • Proficiency. We are proficient in the preparation methods of aerosol preparation, including spray drying, freeze drying and hot melt method, etc.
  • Quality control. Our strict quality control system can ensure the stability and consistency of liposome aerosol preparation.
  • Extensive services. We provide customers with a full range of technical support, including product development, production process optimization and quality problem solving, etc.

Published Data

Technology: liposome inhalation suspension using the eFlow® Technology

Journal: European Journal of Pharmaceutics and Biopharmaceutics

IF : 4.9

Published: 2021

Results : In this study, Meloxicam liposomes, transferrin liposomes, and flavonoid liposomes were developed. The findings demonstrated that the vesicle size of the deformable liposome gel was below 120 nm, with higher encapsulation efficiency compared to conventional liposome gel and non-liposome gel. The prepared deformable liposome gel exhibited excellent permeability and in vitro efficacy.

Fig.2 Liposome inhalation suspension evaluation. Fig.2 Liposome inhalation suspension. (Zhang, Z. J., et al., 2021)

At CD Formulation, our team of scientists is dedicated to solving any issues that may arise during the development process of liposome aerosols. Additionally, our consulting team is committed to providing exceptional consulting services to help advance your project. If you are interested, please feel free to contact us at any time.

References

  1. Rudokas, Mindaugas, et al. Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications. Medical Principles and Practice, 2016, 25 (S2). pp. 60-72.
  2. Zhili Li, Walter Perkins, et al. Robustness of aerosol delivery of amikacin liposome inhalation suspension using the eFlow® Technology. European Journal of Pharmaceutics and Biopharmaceutics, 2021, 166, Pp 10-18.
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