Custom Ultrasound Responsive Liposome Service
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Ultrasound-responsive liposomes are cutting-edge smart delivery systems that enhance ultrasound contrast, enable image-guided drug delivery, and facilitate on-demand drug release under ultrasound stimulation. These liposomes can selectively target specific sites, improving the permeability of physiological barriers such as the cuticle, vascular endothelium, and blood-brain barrier (BBB). Thus, they optimize the efficacy of anticancer agents and minimize side effects. At CD Formulation, we leverage advanced technology and specialized expertise to develop highly responsive ultrasound liposome formulations, supporting researchers in the pharmaceutical industry and other research institutions.
What are Ultrasound Responsive Liposomes?
Ultrasound-responsive liposomes are vesicles that encapsulate drugs and incorporate a small quantity of gas (typically air) within their structure. The drug and gas are sealed within the liposome, making it sensitive to ultrasound, thus enabling ultrasound imaging at low frequencies or controlled release of the contents at high frequencies.
Fig.1 Schematic illustration of the ultrasound-responsive liposome carrier system for cancer targeting. (Sabir, Fakhara, et al., 2021)
Our Ultrasound Responsive Liposome Customization Service
Ultrasound-triggered proliposomes customization service
Our ultrasound-triggered proliposomes are generally composed of lipid materials modified by acoustic sensitizer and containing drugs. This liposome can maintain stability in blood circulation, has no cytotoxicity, and has no side effects on normal tissue cells. Some liposomes enter and accumulate in tumor tissues and internalize into tumor cells. Under ultrasonic irradiation, acoustic sensitizers trigger prodrug activation and release cytotoxic anticancer drugs to induce tumor cell apoptosis in a time-space-controlled manner.
Ultrasound responsive liposome customization service
At CD Formulation, we offer multiple highly sensitive ultrasound-responsive liposomes for different applications, including diagnostic imaging, anti-cancer, and bone regeneration. Besides traditional types, we can provide some liposomes based on new techniques, including carbon dioxide-loaded liposomes (supercritical CO2 (scCO2) technique), submicron nanobubble-liposome complex, and ultrasonic cavitation phase transition liposomes.
Study on the mechanism of ultrasound triggered in liposomes
The systematic study of the mechanism of ultrasound-triggered liposome release can help optimize the preparation process and formulation of liposomes and develop more sensitive ultrasound-responsive liposome products.
Fig.2 Schematic diagram of our workflow. (CD Formulation)
Our Platforms for Ultrasound Responsive Liposome Customization
We have established a proprietary platform for ultrasound-responsive liposomes and can offer the following technologies.
| Techniques and Platforms |
Specifics |
| Ultrasound Responsive Delivery Techniques |
This platform supports various ultrasound-responsive liposomes (including carbon dioxide-loaded liposomes, submicron nanobubble-liposome complex, and ultrasonic cavitation phase transition liposomes). |
| Ultrasound Responsive Liposome Development Techniques |
- Ultrasonic-stimulus response is combined with other internal factor response techniques, such as pH, temperature, ROS, etc.
|
| Characterization Platform |
- Physical and chemical properties.
- In vitro (such as release, cytotoxicity, cell uptake, etc.) and in vivo characterization (such as biological activity, in vivo distribution experiment).
|
Why Choose CD Formulation?
- Top technical team. Our research team is focused on ultrasound-responsive liposome delivery systems, which is a team of scientists who are proficient in immunology, medicine, biology, and related disciplines, and have extensive experience in developing intelligent biological delivery systems.
- Unique and advanced platforms for the development of smart ultrasound-responsive delivery systems. At this platform, technologies are available for ultrasound-responsive liposome customization, including supercritical fluid technology, precursor liposome development technology, and vesicle and liposome conjugation technology. Our platform also supports exploring the potential for multiple responses to work synergistically within liposomes.
- Customized diversification. Our ultrasound-responsive liposome products can be customized to meet the specific research and application requirements of various industries, incorporating a wide range of stimulus-response mechanisms. These applications include, but are not limited to, medical research, drug delivery systems, contrast agent development, biosensors, cell engineering, agriculture, and botany.
Published Data
Technology: Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery Technique
Journal: Frontiers in Pharmacology
IF: 4.4
Published: 2019
Results: In this study, the authors investigated the encapsulation of mistletoe lectin-1 (ML1) in ultrasound-sensitive liposomes (USL) and investigated its release via high-intensity focused ultrasound (HAccessedIFU). USL was prepared by encapsulating perfluorocarbon nanodroplets in pegylated liposomes. HRP release in USL triggered by HIFU was studied to optimize the composition of the liposome. It was found that the USL-triggered release rate with USL10 (60/30/10) lipid composition was 80%. The final ML1 release rate in the USL10 composition is also 80%. Given its high stability, suitable release, and ultrasonic sensitivity, the biological activity of released ML1 against mouse CT26 colon cancer cells was further investigated using USL10 encapsulated ML1. The study shows that USL combined with HIFU is expected to be trigger-sensitive nanomaterials for local delivery of macromolecular cytotoxins.
Fig.3 TEM image of the ultrasound-sensitive liposome. (de Matos MBC, et al., 2019)
CD Formulation has developed an outstanding platform for ultrasound response liposomes to offer our customers a range of extremely responsive liposome products. Please feel free to contact us if you need any assistance.
References
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Sabir, Fakhara & Zeeshan, Mahira & et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. Cancers. 2021
- de Matos MBC, Deckers R, et al. Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization. Front. Pharmacol. 2019. 10:1463.
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