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Custom Ultrasonic Switchable Fluorescence Imaging Near-infrared Liposome Service

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Fluorescence imaging is a vital tool for molecular targeting and multicolor imaging, but traditional methods are limited by tissue depth. The development of ultrasound-switchable fluorescence (USF) imaging addresses this by enabling high-resolution imaging with the help of specialized contrast agents. CD Formulation is committed to advancing liposome technology for in vivo imaging focusing on developing stable ultrasonic switchable fluorescence imaging near-infrared liposomes.

What are Ultrasonic Switchable Fluorescence Imaging Near-infrared Liposomes?

USF imaging is a non-invasive technique that utilizes ultrasound-induced thermal energy to achieve high-resolution imaging of deep tissue structures. The contrast agent used in USF imaging emits a strong fluorescence signal when exposed to ultrasound-induced thermal energy and is selectively activated within the ultrasound focal volume where the thermal energy exceeds its switching threshold. For instance, ICG-loaded liposomes function as a type of USF contrast agent capable of enhancing imaging sensitivity and depth, with the size of the liposomes influencing the amount of ICG released upon ultrasound triggering; typically, 50 nm ICG-loaded liposomes release more ICG than their 200 nm counterparts.

Fig.1 Ultrasound-controlled fluorescence mechanism for deep tissue optical imaging using liposomes. Fig.1 Mechanism of ultrasound-controlled fluorescence technique in optical imaging of deep tissue. (Liu RL, et al., 2022)

Our Custom Ultrasonic Switchable Fluorescence Imaging Near-infrared Liposome Services

Liposome Customization

Compared to traditional near-infrared (NIR) fluorescence imaging, ultrasound-controlled fluorescence (UCF) technology offers enhanced resolution for biomedical applications. We can offer custom solutions including sonosensitive phase-changeable nanoparticles, thermosensitive liposomes, and temperature-responsive nanoparticles, tailored for your specific in vivo imaging needs.

Liposome Characterization

The effectiveness of in vivo USF imaging relies on the physiological stability of the probes. We offer comprehensive in vitro and in vivo assessments, including:

Cell targeting, apoptosis, and viability assays.
Phase transition and ultrasound imaging tests.
Evaluation of liposome performance under ultrasound-induced conditions.

Our Expertise in Customizing Ultrasonic Switchable Fluorescence Imaging Liposomes

Techniques & Platforms	Details
Ultrasonic Switchable Fluorescence Imaging Liposome Technology	Effective for both in vitro and in vivo near-infrared upconversion fluorescence imaging, enhancing signal with nanoscale azobenzene emitters.
Characterization Platform	Equipped with advanced tools like NucleoCounter NC-250, Moxi GO II cytometer, and ZERO fluorescent cell imaging systems.

Why Choose CD Formulation?

Advanced Ultrasonic Switchable Fluorescence Imaging Technology: Combining ultrasound-controlled fluorescence and liposome technology, our solutions support high-resolution in vivo imaging, widely used in basic research.
Robust Characterization Platform: Comprehensive analytical services help clients study the stability and behavior of targeted liposomes both in vitro and in vivo.
Experienced Professional Team: Led by experts in molecular biology, chemistry, and pharmaceutical sciences, we apply interdisciplinary methods including AI and materials chemistry to innovate custom liposome solutions.

Published Data

Technology: ICG-encapsulated liposome technique

Journal: Advanced Healthcare Materials

IF: 10.5

Published: 2020

Results: In this study, a novel indocyanine green (ICG)-encapsulated liposome was introduced to broaden the selection range of ultrasound-switchable fluorescence (USF) imaging contrast agents and address the aforementioned challenges. The emission peak of ICG-liposome is at 836 nm, exhibiting excellent bio-stability and USF imaging capability. Furthermore, cell viability tests confirmed its low toxicity. Ultimately, successful USF imaging was achieved in vitro and in vivo, yielding 3D USF images. In vitro results validated the thermo-responsive property maintenance of ICG-liposome in the right lobe of the liver along with its USF imaging ability. Further observations from live animal USF imaging demonstrated that while fluorescence was emitted throughout the entire liver, active ICG-liposomes were only present in the right lobe.

Fig.2 Excitation and emission spectra of the aqueous ICG solution and the ICG-liposome. Fig.2 Excitation and emission spectra of a) the aqueous ICG solution and b) the ICG-liposome. (Liu Y, et al., 2020)

As a leader in nanoparticles, CD Formulation is dedicated to delivering exceptional ultrasonic switchable fluorescence imaging near-infrared liposomes for in vivo imaging applications. Please do not hesitate to contact us if you require any assistance.

References

Liu RL, Cai RQ. Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging. J Pharm Anal. 2022 Aug; 12(4): 530-540.
Liu Y, Yao T, et al. A Biocompatible and Near-Infrared Liposome for In Vivo Ultrasound-Switchable Fluorescence Imaging. Adv Healthc Mater. 2020; 9(4): e1901457.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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