Custom Temperature-ultrasonic Responsive Liposome Service

Temperature-ultrasound responsive liposomes are emerging as an effective system for delivering sensitive drugs to tumor cells, allowing precise targeting of deep tissue. CD Formulation is dedicated to developing intelligent liposomes using cutting-edge technologies and expertise to produce high-performance liposomes that respond to temperature and ultrasound.

Mechanism of Temperature-ultrasonic Responsive Liposomes

Temperature-sensitive or thermosensitive liposomes (TSLs) are among the most effective types of nanocarriers for site-specific drug delivery applications. Ultrasound, a high-frequency (≥ 20 kHz) mechanical wave that can be focused and transmitted through certain media, has been widely utilized in various clinical applications due to its non-invasive and cost-effective benefits. Furthermore, high-intensity focused ultrasound (HIFU) can induce tumor thermal ablation by generating elevated temperatures through prolonged and continuous exposure. Therefore, the strategic combination of ultrasound stimulation with photodynamic liposomes has the potential to enhance local drug delivery to the tumor significantly.

Fig.1 Illustrative diagram of liposome mechanism triggered by heat/ultrasound. (Jiani Yuan, et al., 2023)

Our Temperature-ultrasonic Responsive Liposome Customization Service

Study on ultrasonic-triggering mechanism

The mechanism underlying ultrasound-induced drug delivery remains poorly understood. Some research suggests that this process may be attributed to the thermal and non-thermal effects of ultrasonic radiation energy. The thermal effect mainly converts sound energy into heat energy, while the non-thermal effect is related to cavitation phenomena. Different ultrasonic methods are suitable for different frequencies and materials. By studying this mechanism, we aim to help customers understand cavitation effects more specifically, for example investigating the impacts of ultrasound pulses on drug release at varying frequencies of ultrasound.

Study on temperature-triggering mechanism

In general, ultrasonic triggering is often accompanied by hyperthermia, complicating the study of cavitation's effect on lipid-based nanocarriers in isolation. We aim to offer this service to assist customers in investigating the impact of different temperature triggers on drug release and identifying suitable temperature-sensitive polymers.

Ultrasound-responsive polymer & thermosensitive polymer (TSP) synthesis

The screening and synthesis of ultrasound- and temperature-sensitive polymers are essential for developing sensitive copolymers responsive to both ultrasound and temperature. These copolymers can be utilized in the formulation of bi-sensitive liposomes responsive to both temperature and ultrasound.

Product application scenario research

The service assists clients in comprehending and exploring the utilization of tailored products and the release during specific usage.

Fig.2 Our workflow for temperature-ultrasonic responsive liposome customization. (CD Formulation)

Our Platforms for Temperature-ultrasonic Responsive Liposome Customization

Why Choose CD Formulation?

• First-class Surface Grafting Techniques. For many years, we have continuously strived to assist our customers in the development of multi-responsive polymers and copolymers, as well as in the utilization of liposome surface conjugation technology for liposome modification.
• Smart ultrasonic/temperature-responsive delivery system development platform. The platform supports ultrasonic-temperature dual-responsive liposome formulation, process optimization, and analytical characterization (in vitro and in vivo).
• Top technical team. Our technical team comprises highly proficient scientists specializing in fields such as medicine, biology, immunology, and synthesis, possessing extensive expertise and experience in ultrasound-temperature dual-responsive liposomes.

Published Data

With state-of-the-art technology and platforms, CD Formulation is dedicated to delivering intelligent temperature/ultrasonic dual-responsive liposomes to our customers. If you require any assistance, please do not hesitate to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.