Custom pH-temperature Responsive Liposome Service

The pH-temperature responsive liposome delivery system is highly regarded for its ability to precisely target cancer cells within deep tissues by responding to both temperature and pH changes. CD Formulation supports the development of intelligent liposomes through the application of state-of-the-art technology and professional expertise to design high-performance liposomes with dual temperature and pH responsive capabilities.

Mechanism of pH-temperature Responsive Liposomes

By incorporating pH-sensitive polymers into liposomes and utilizing thermosensitive polymers such as DMPC, DPPC, DSPC, etc. as the liposome membrane material, composite thermosensitive liposomes responsive to both pH and temperature can be developed. Upon endocytosis by cells, these liposomes accumulate in acidic pH organelles (endosomes and lysosomes) or cancer tissues. When the tumor site is subjected to heat, simultaneous triggers of pH and temperature stimulation lead to reorganization or rupture of the liposome membrane structure, altering its permeability to release anticancer drugs. Therefore, dual-stimulus (temperature and pH) sensitive liposomes benefit for precise drug delivery deep within tissues. While single-sensitive liposomes already exhibit effective targeting and utilization for cancer cells, dual-sensitive liposomes offer distinct advantages including a straightforward preparation process, versatile applications, and heightened sensitivity to cancer cells.

Fig.1 Schematic of PASP-g-C8 modified composite pH/temperature-sensitive liposomes. (Yilin Zhao, et al., 2020)

Our pH-temperature Responsive Liposome Customization Service

Study on pH-temperature dual responsive strategy

Through this service, we help clients explore the pH and temperature response mechanisms, as well as access screening services for each response trigger, including temperature trigger factors (e.g. drug release under various light exposures (such as lasers)).

Polymers and copolymers synthesis and screening

The service is primarily utilized for screening monomers of temperature-sensitive polymers and pH-sensitive polymer monomers, matching and synthesizing dual-sensitive (pH and temperature) copolymers, as well as determining the conformational transformation mechanism of polymer chains following heat exposure through DSC measurements of absorption peaks and homogenization points.

Temperature-sensitive lipid material screening

This service helps clients screen suitable thermosensitive lipid materials such as DMPC, DPPC, DSPC, etc.

Liposome surface grafting service

This service entails liposome grafting with polymers and copolymers, achieving a dual-responsive effect by grafting thermosensitive or pH-sensitive polymers onto the liposome surface.

Application services

The service integrates the client's intended application with customized dosage forms, such as hydrogels for transdermal formulations and injectables for targeted delivery.

Fig.2 Our workflow for custom pH-temperature responsive liposome service. (CD Formulation)

Our Platforms for pH-temperature Responsive Liposome Customization

Why Choose CD Formulation?

• First-class pH temperature dual sensitive development technology. For many years, we have been dedicated to the development of intelligent liposome delivery systems tailored to different response stimuli. Our extensive experience includes the advancement of pH/temperature dual-responsive liposomes, as well as the development of pH/temperature dual-responsive polymers and copolymers, along with liposome surface conjugation technology using branched polymers.
• Smart pH/temperature-responsive delivery system development platform. The platform supports the development of pH-temperature dual-responsive liposome formulations, process optimization, and analytical characterization (in vitro and in vivo).
• Top technical team. Our technical team consists of highly skilled scientists specializing in chemistry, immunology, medicine, biology, and related fields. They have extensive expertise in developing pH-temperature bi-responsive liposomes.
• Flexible customization scheme. Our pH-temperature dual-responsive liposome formulations can be tailored to suit the requirements of diverse sectors, encompassing pharmaceutical delivery, medical imaging, cellular manipulation, and agricultural applications.

Published Data

With state-of-the-art technology and platforms, CD Formulation is dedicated to delivering intelligent pH-temperature dual-responsive liposomes to our customers. If you require any assistance, please do not hesitate to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.