Custom Multivesicular Liposome Service

Over the past decade, multivesicular liposomes (MVL) have shown significant progress in continuous drug delivery, offering high encapsulation efficiency, structural stability, size variability, and diverse delivery routes. CD Formulation leverages cutting-edge technologies and expertise to develop high-performance, intelligent multivesicular liposomes to meet specific research needs.

Mechanism of Multivesicular Liposomes

Multivesicular liposomes (MVL) are micrometer-sized spherical particles composed of non-centrosymmetric lipid bilayers, enclosing drug molecules within their internal aqueous compartments. This polyhedral structure ensures the integrity and sustained release of small molecules, peptides, or proteins during non-vascular administration. The release of multivesicular liposomes follows a three-phase pattern. Initially, there is the rapid release of the free drug followed by a sudden burst of the drug. This is then succeeded by a slower lag phase in the release rate, attributed to the reorganization of the lipid membrane. At temperatures above the lipid phase transition, membrane fusion occurs, leading to the collapse of the honeycomb structure. The final stage involves secondary release caused by erosion due to lipid hydrolysis.

Fig.1 Schematic plot of the speculated drug release mechanism of MVL particles. (Chaurasiya, A., et al., 2022)

Our Multivesicular Liposome Customization Service

Formulation study and parameter optimization

We offer formulation studies and parameter optimization such as charged phospholipids, cholesterol, neutral lipids, process temperature, process time and shear, etc.

Study on the route of administration

Multivesicular liposome drug delivery can be achieved via various administration routes, such as intramuscular, subcutaneous, intravenous, subarachnoid, intra-articular, intravitreal, and epidural injections. We can provide research on diverse methods of drug delivery.

Characterization analysis

We provide physical and chemical characterization (particle size, charge distribution, charge load and encapsulation rate, viscosity, rheology, appearance, internal and external pH, internal and external ionic strength, stability, etc.). In vitro characterization services include cell uptake rate assay, cytotoxicity assay, and evaluation of tumor cell-targeting ability. In vivo characterization services such as in vivo distribution analysis, in vivo bioactivity analysis, in vivo stability analysis, etc.

Our Platforms for Multivesicular Liposome Customization

Why Choose CD Formulation?

• Top multivesicular delivery platform. The platform supports the development of innovative multi-capsule liposome products, allows the study of their reaction mechanisms, and provides customers with system customization services including formulation development, mechanism research, in vitro and in vivo release studies, etc.
• Techniques for multivesicular liposomes. We possess sophisticated technology for multi-vesicular liposomes, encompassing preparation and characterization techniques, to ensure the delivery of high-quality customized products to our clients.
• The proficient teams. The technical team comprises seasoned and highly skilled experts proficient in multivesicular liposome technology, with diverse multidisciplinary backgrounds and extensive knowledge in the field.

Published Data

As a leading company in nanoparticle development, CD Formulation is dedicated to providing excellent multivesicular liposome products. Please do not hesitate to contact us if you require any assistance.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.