Custom GSH-liposome Service

Glutathione (GSH) grafted onto nanoliposomes (GSH-liposomes) has the potential to enhance drug entry into the brain. As a global pharmaceutical research and development company, CD Formulation has extensive experience in nanodelivery systems development and has its nanoformulation development technology. We have been committed to advancing the development of relevant research by customizing high-quality GSH-liposomes. At the same time, we can quantify the binding process of GSH with liposomes and study the stability of GSH during the binding process.

What Are GSH-liposomes?

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine, containing a thiol group. GSH exists primarily in two forms: reduced (GSH) and oxidized (GSSG). Functionally, GSH serves as a cofactor for glycerol-3-phosphate dehydrogenase and an auxiliary factor for aldose reductase and glucose-6-phosphate dehydrogenase. It plays a critical role as a cellular regulator and is involved in the tricarboxylic acid cycle and glucose metabolism. Moreover, it can activate various enzymes as a thiol (SH) enzyme cofactor, promoting the metabolism of carbohydrates, fats, and proteins. GSH-liposome formulations offer distinct advantages for applications in cosmetics, pharmaceuticals, and dietary supplements.

Fig.1 Schematic diagram of glutathione conjugation to liposomes. (Joy N. Reginald-Opara, et al., 2019)

Explore Our Custom GSH-liposome Service

GSH-liposome Customization for Research Use

The service mainly provides biomimetic nanoparticles with glutathione-consuming capacity. We contribute to the relevant research areas by providing customized GSH-responsive liposome products. In general, these liposomes contain a molecule that reacts with excess glutathione (GSH) in tumor cells, resulting in the depolymerization of the liposomes, the release of the drug, and the depletion of GSH, which weakens the antioxidant capacity of the tumor cells.

Cosmetic Glutathione Liposome Customization

Glutathione is widely utilized in the beauty and skincare industry for its ability to decelerate skin aging, improve skin radiance and smoothness, diminish pigmentation, and rejuvenate damaged skin cells. This is attributed to its potent antioxidant properties and unique capacity to inhibit melanin production. Our proprietary platform-encapsulated glutathione liposomes exhibit exceptional penetration and absorption capabilities.

Oral Supplementation Customization

Glutathione is an important antioxidant that is found in every cell of the body. It also helps regenerate other antioxidants, such as vitamins C and E, but glutathione breaks down very quickly in the body, making it impossible to reach the cells that need it. Our glutathione dietary supplement products leverage liposome drug delivery technology to encapsulate glutathione in liposome structures, enhancing its tolerance during the digestive process after oral administration. This results in faster and longer-lasting effects within the body, maximizing the supplement's benefits.

Our Capabilities for Customizing GSH-liposomes

Applications of GSH-liposomes

• Dietary supplement. The liposomal formulation protects glutathione bonds from degradation during digestion, facilitating enhanced absorption and supporting antioxidant defense and detoxification.
• Medical research. Combined with numerous immunotherapy strategies for medical research: chemical immunotherapy, Photodynamic therapy, Iron death therapy for lung cancer, etc.
• Cosmetics industry. Glutathione is thought to have anti-melanin production properties, which may be attributed to inhibiting tyrosinase, affecting melanin production and free radical scavenging. GSH-liposome offers unlimited possibilities for its application in cosmetics.

Our Key Advantages in Customizing GSH-liposomes

• Skilled teams. Our development team consists of several scientists, who are proficient in immunology, medicine, biology, and other multi-disciplines, and have rich experience in the biological delivery systems, especially the GSH-liposome system.
• Perfect evaluation system. Our analytical department is divided into several parts, such as physical and chemical analysis group, in vitro efficacy evaluation group, in vivo evaluation group, systematic evaluation, and screening of customized products.
• Flexible and customized services. According to the needs and objectives of our customers, we provide flexible design service solutions, aiming to provide products that meet the needs of customers.

Published Data

The CD Formulation has successfully established the GSH-liposome development platform and is capable of providing a diverse range of GSH-liposome products. If you require any assistance, please feel free to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.