Transdermal gene therapy is an emerging method of gene therapy, that delivers therapeutic genes to target cells or tissues through the skin, it shows good application value in gene therapy, especially in skin diseases. CD Formulation engages in gene therapy research and provides comprehensive and reliable technical support to researchers, especially in transdermal gene therapy formulation development.

Advantages of Transdermal Gene Therapy Formulation

• Non-invasive. Transdermal gene therapy delivers genetic material through the skin, avoiding invasive operations such as injections and reducing pain and discomfort for patients.
• Localized treatment. The method enables efficient delivery of genetic material to localized skin tissues, treating specific areas and reducing systemic side effects.
• Sustained release. Transdermal formulations can be designed as sustained-release systems, ensuring that the genetic material is released continuously over some time, enhancing the therapeutic effect.
• Convenience. Patients can self-treat by applying a compress or coating of the formulation, which is easy to do and increases compliance with treatment.

Explore Our Transdermal Gene Therapy Formulation Development

Drug screening and formulation design

To select drugs suitable for transdermal delivery, consider their physicochemical properties, such as lipophilicity, molecular weight, etc., and design formulations to optimize the transdermal absorption of the drugs. In this part, we need to optimize the transdermal delivery vehicle, such as designing a liposome-based dual-drug delivery system or constructing composite nanoparticles, which are novel transdermal delivery vehicles that will show more potential for development.

Transdermal enhancer research

Development of chemical enhancers or the use of external energy sources to improve drug penetration into the skin, such as microneedling technology. Microneedle technology can bypass the skin barrier for drug and gene delivery, which has the advantages of simplicity, safety, and painlessness, and can transfer large molecule drugs and genes with good reproducibility.

Formulation process development

Including mixing of drugs and excipients, preparation of micro-needles, molding of patches, etc., to ensure the quality and efficacy of formulations.

In vitro evaluation and in vivo experiment

Evaluate the quality of the formulation through in vitro release and transdermal absorption tests, and further evaluate the in vivo efficacy and safety through animal models.

Fig.2 Role of transdermal gene therapy formulation. (CD Formulation)

Applications of Our Transdermal Gene Therapy Formulation Development

Currently, transdermal gene therapy formulations have a wide range of applications, which can be used not only for skin cancer treatment, vaccination, and wound healing but also in other therapies for effective delivery of gene therapy.

• Skin diseases. Skin is the most exposed and self-renewing organ in the human body. Epidermal stem cells in the basal layer of the skin maintain the barrier function of the body through proliferation, differentiation, and finally the formation of the stratum corneum. The key to treating hereditary skin diseases lies in the development of new technologies and materials that are painless, safe, specific, and highly effective in delivering gene drugs to the basal layer of the epidermis, where they can be taken up by the epidermal stem cells and repair the gene mutations. Currently, transdermal gene therapy formulations have been able to show good application results in hereditary skin diseases and inflammatory skin diseases.
• Transdermal drug delivery systems for cancer therapy. Transdermal drug delivery systems offer an attractive option for cancer treatment, allowing for the subcutaneous administration of a wide range of anticancer therapeutics from lipophilic small molecules to hydrophilic biomolecules. In addition, activation of the skin's immune system can assist in the treatment of distal sites.
• Enhancing the penetration effect of nano-formulations. The penetration of nano-formulations can be further enhanced by applying physical pro-permeability means together with nano-transdermal formulations. For example, microneedle technology can bypass the stratum corneum barrier and release drugs directly into the skin tissue, showing great potential for transdermal drug delivery.

Our Platforms for Transdermal Gene Therapy Formulation Development

Highlights of Our Transdermal Gene Therapy Formulation Development

• Professional R&D team. We have a specialized research and development team focusing on the research and development of gene therapy and transdermal delivery technologies.
• Innovative technology platform. Based on microneedle technology, nanoparticle carrier system and liposome delivery system, we are continuously improving the efficiency and safety of gene therapy.
• Numerous partners. To date, we have established partnerships with several academic institutions, medical research centers and other biotechnology companies to facilitate knowledge sharing and technology exchange.
• Customized solutions. We can provide customized transdermal gene therapy solutions according to the needs of different diseases and patient groups.

Published Data

CD Formulation is a leader in the field of gene therapy, and we specialize in providing comprehensive technical support for the development of gene therapy formulations that address the issues faced by investigators in gene therapy research. If you are interested in us, please feel free to contact us.