Peptide & Protein PLA Microsphere Development

At CD Formulation, our team comprises highly skilled scientists with extensive experience in the development and characterization of polylactic acid (PLA) microspheres for peptide and protein delivery. We leverage our expertise to provide tailored PLA microsphere development services that meet the unique requirements of each client and their specific drug candidates.

Why Choose PLA Microspheres to Deliver Peptide and Protein?

Protein and peptide drugs are highly effective at eliciting therapeutic activity due to their specific interactions with biological targets. However, their administration often requires repeated doses due to their short half-lives and rapid clearance from circulation. Polymer microspheres offer a promising solution by encapsulating proteins and peptides. Long-acting injectable (LAI) microspheres, particularly those based on biodegradable polymers like PLA, have gained attention for their high drug loading, prolonged release, and improved patient compliance.

SEM images of PLA microspheres (Watanabe T.; et al. 2011)

How Do We Develop PLA Microspheres for Peptide & Protein Delivery?

Our team works closely with clients to understand their specific goals and requirements, ensuring a customized approach throughout the development journey. Key steps in our development process include:

• Formulation Design

We carefully select the appropriate PLA polymer and optimize its composition to achieve desired release kinetics and stability. Formulation parameters, such as drug loading, polymer concentration, and excipient selection, are tailored to achieve optimal encapsulation efficiency and controlled release.

• Microsphere Fabrication

At CD Formulation, we leverage decades of expertise across multiple microencapsulation platforms to fabricate optimized PLA microspheres. Techniques such as emulsion-solvent evaporation, spray drying, microfluidics, and precision particle fabrication equip us to tightly control critical parameters based on the drug payload. State-of-the-art facilities and equipment ensure reproducible fabrication and scale-up processes to smoothly transition PLA microspheres from lab to market.

• Characterization

In order to better optimize the formula and process, we will conduct an in-depth analysis of the characteristics of PLA microspheres. By exploring release kinetics, polymer degradation rates, and peptide/protein stability under various temperature, pH, and enzymatic conditions that reflect physiological environments, we will gain a deeper understanding of the complex properties and behavior of microspheres. This rigorous characterization serves as a guiding guide, allowing us to refine and optimize our formulations, ensuring their efficacy, safety, and suitability for the intended therapeutic application.

Our Technology Platforms for PLA Microsphere Characterization

Advantages of Our Peptide & Protein PLA Microsphere Development Services

• PLA microspheres can be degraded by microorganisms into harmless substances (lactic acid) in the body.
• By controlling parameters such as the molecular weight, concentration, and preparation process of polylactic acid, we can regulate the size and distribution of PLA microspheres.
• We can introduce functional groups such as hydroxyl and carboxyl groups on the surface of PLA microspheres to change their properties and functions.
• The PLA microspheres we developed can be widely used in tissue engineering, regenerative medicine, drug delivery and other fields.

CD Formulation provides full-service expertise throughout the product lifecycle. If you are seeking a reliable partner for the development of PLA microspheres, please contact us to discuss how custom formulations can maximize the therapeutic potential of your peptide or protein candidates.