Peptide & Protein Nasal Spray Development
InquiryThrough the highly vascularized nasal mucosa, nasal administration provides a non-invasive route for drug delivery, rapid absorption, and a bypass of gastrointestinal degradation. At CD Formulation, our efforts are focused on overcoming formulation challenges, optimizing delivery device design, and exploring clinical applications of protein-based nasal sprays.
Progress in R&D of Peptide & Protein Nasal Spray
Several pharmaceutical companies have developed nasal sprays containing peptides and proteins to deliver drugs, which have advantages in terms of absorption and systemic circulation. Marketed examples include miacalcin nasal spray, containing synthetic calcitonin salmon for osteoporosis treatment, and desmopressin nasal spray, used for conditions like diabetes insipidus and bedwetting. Oxytocin nasal sprays aid in labor induction and breastfeeding support.
What Can We Do for Peptide & Protein Nasal Spray Development?
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Target Confirmation
For specific diseases or symptoms, we can assist customers in researching and determining the target and mechanism of action of drugs, providing guidance for subsequent drug design and screening.
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Active Ingredient Screening
Based on drug targets and mechanisms, we can help customers design and screen peptide and protein drugs with specific activity, stability and safety.
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Formulation Development
According to the characteristics and uses of the drug, suitable excipients and preparation processes are selected to develop safe, effective and stable nasal spray preparations.
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Physical and Chemical Analysis
- Particle size and particle size distribution
- Density and viscosity
- Surface tension
- Ingredient analysis
- Stability analysis
What Excipients are Needed to Develop Peptide and Protein Nasal Sprays?
| Carrier |
We often dissolve or mix peptide drugs with biodegradable polymer materials to form microspheres, nanosuspensions, liposomes and other preparations to increase the retention and effectiveness of the drug in the nasal mucosa. |
| Surfactants |
Drugs can be made more soluble and stable by adding surfactants. Commonly used ones include lecithin, poloxamer, sodium chloride, etc. |
| Mucoadhesive Agents |
Mucoadhesive agents like hydroxypropyl cellulose (HPC), carbomers, or chitosan derivatives are utilized to enhance nasal retention and prolong contact time with the nasal mucosa. |
| Penetration Enhancers |
Penetration enhancers, such as cyclodextrins or fatty acids, can be incorporated to enhance the permeation of peptides and proteins across the nasal mucosa, facilitating their systemic absorption. |
| Osmotic Agents |
Osmotic agents, like sodium chloride or glycerin, can be included to adjust the osmolarity of the nasal spray formulation, matching the physiological conditions of the nasal cavity and minimizing irritation. |
| Stabilizers |
Stabilizers such as sugars (trehalose, sucrose) and polyols (mannitol) are often used to protect peptides and proteins from degradation, maintain their structural integrity, and prevent aggregation during formulation and storage. |
| Preservatives |
In order to prevent contamination by bacteria, preservatives are used. Commonly used ones include sodium benzoate, potassium sorbate, etc. |
Why Choose Our Peptide & Protein Nasal Spray Development Services?
- Strong technical strength: From peptide and protein design to screening and optimization, we offer a full range of research and development capabilities.
- Quality assurance: We focus on product quality and have established a strict quality control system to ensure that all aspects from raw material procurement to production and packaging meet the requirements.
- Fast delivery: We can complete the development of nasal sprays in a short time to meet customers' urgent needs.
- Customized services: We provide customized services based on customer needs, including product formula, fragrance, usage experience and other personalized requirements.
CD Formulation employs advanced formulation techniques to ensure the stability and integrity of peptides and proteins throughout the development process. Our scientists and researchers understand the unique challenges associated with formulating and delivering these complex molecules via nasal sprays, ensuring optimal outcomes. Inquire now and let us be your trusted partner in the peptide and protein formulations!
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