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At CD Formulation, we leverage decades of expertise in microencapsulation technology to develop customized PLGA and other polymer microspheres for improved delivery of peptide, protein, and antibody therapies. Our experienced scientists can engineer microspheres with tailored release kinetics, functionalized surfaces, and excellent drug loading to overcome the barriers of biologic drug delivery.
Drugs are continuously dissolved and diffused into the external environment through pores in porous microspheres so that they can exert their medicinal effects. In order to control the release of drug, we adjust the formula and process to change the number of holes in the spheres. This reduces the surface area and drug loading capacity of the microspheres.
There is a core-shell structure to double-layer microspheres. Our microspheres feature an outer shell made of degradable polymer material coated with drugs as well as a biodegradable polymer material for the core. When compared to microspheres with pores, double-layer microspheres release mainly based on their core-shell structure. It is because of their high sealing and encapsulation rates that double-layer microspheres are able to carry a large amount of drug and have high loading capacities.
Magnetic microspheres are modified based on the first two microspheres. At CD Formulation, we make ultra-fine powders from magnetic metals or metal oxides and disperse them in polymer materials or drugs to produce magnetic microspheres, which can move to targeted organs or tissues under the influence of an external magnetic field.
Structures | ||||
Types | Poly (lactic-co-glycolic acid), PLGA | Polylactic acid, PLA | Poly(ε-caprolactone), PCL | Polyglycolide, PGA |
We carefully choose biodegradable polymers that meet the specific requirements of the project, considering factors such as biocompatibility, degradation kinetics, and encapsulation efficiency.
Our experts leverage their extensive knowledge of polymer science and drug delivery to optimize the formulation parameters, including polymer concentration, solvent selection, and emulsification techniques, to achieve the desired encapsulation efficiency and release kinetics.
Using advanced techniques, we precisely encapsulate the peptides and proteins within the microspheres, ensuring their stability and protection during storage and delivery.
After separating the microspheres from the system, we can effectively control the residual amounts of organic solvents and toxic substances by optimizing the curing method, temperature, time, and cleaning methods.
This includes comprehensive analytical characterization of size, morphology, charge, drug loading and release kinetics.
CD Formulation specializes in designing and optimizing biodegradable microspheres tailored to encapsulating and delivering peptides and proteins. If you're seeking innovative solutions for targeted and efficient drug delivery, contact us today!