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Peptide & Protein Gold Nanoparticle Development

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CD Formulation is committed to using advanced nanotechnology to provide innovative solutions to the global pharmaceutical industry. Our core business is the development of high-quality gold nanoparticles for drug delivery. These particles offer significant advantages in the delivery, stability, and efficacy of peptides and proteins. Our services include full tracking from particle design and production to application testing to ensure customers receive the highest quality products.

Applications of Gold Nanoparticles in Drug Delivery

Gold nanoparticles are nanomaterials with excellent physical and chemical properties, and their applications in the medical field have attracted widespread attention. We exploit the unique properties of gold nanoparticles, such as high electron density, surface plasmon resonance effect, etc., making them ideal carriers for drug delivery. We can also functionally modify gold nanoparticles according to customer needs to achieve precise delivery of peptides and proteins in the body.

Formation and mechanism of action - BH3 peptide gold nanoparticles (Zhang X.; et al. 2023)Formation and mechanism of action - BH3 peptide gold nanoparticles (Zhang X.; et al. 2023)

Types of Gold Nanoparticles We Develop for Peptide and Protein Delivery

  • Surface-Modified Gold Nanoparticles

We can design gold nanoparticles with surface modifications, attach peptide or protein modifications to the gold nanoparticle surface, or polyethylene glycol to improve stability, extend circulation time, and facilitate targeted delivery to specific cells or tissues.

  • Hollow Gold Nanospheres

We develop hollow gold nanoparticles with a unique structure that allows for the encapsulation of therapeutic peptides and proteins within the hollow core. This design offers enhanced payload capacity and controlled release capabilities.

  • Gold Nanorods

Our expertise extends to the development of gold nanorods, which possess unique optical properties and can be utilized for both drug delivery and imaging applications. Surface modifications enable targeted delivery and imaging of peptides and proteins.

Our Peptide & Protein Gold Nanoparticle Development Process

  • Nanoparticle Optimization

    Evaluate and select gold core size, shape, and surface coatings to match delivery requirements.

  • Surface Functionalization

    Conjugate targeting ligands, stabilizing polymers, and stealth coatings onto the gold surface.

  • Drug Loading

    Develop optimized loading methods to adsorb, entrap, or covalently bind the peptide/protein onto the nanoparticle matrix.

  • Characterization

    Use TEM, DLS, ZETA potential, FTIR, ICP-MS, and other techniques to comprehensively analyze quality attributes.

  • Formulation

    Apply stabilizing excipients and delivery-enhancing strategies to improve pharmacokinetics and efficacy.

  • Process Development

    Refine and scale up manufacturing methods from benchtop to cGMP processes ensuring quality and batch consistency.

Our Gold Nanoparticle Technologies

  • Scalable manufacturing processes enable the large-scale production of gold nanoparticles.
  • Microfluidic synthesis methods offer unparalleled control over size and uniformity.
  • Novel surface ligands and polymer coatings to minimize opsonization and off-target effects.
  • Light-triggered release mechanisms for spatiotemporal control of drug delivery.
  • Hybrid nanoplatforms combine gold with siRNA, microRNA, or CRISPR elements.
  • Bioorthogonal chemistry for site-specific conjugation and oriented immobilization of biologics.

Highlights of Our Peptide & Protein Gold Nanoparticle Development Services

  • Multidisciplinary experts in pharmaceutical science and nanotechnology
  • High biocompatibility and non-toxicity based on an inert gold core
  • Enhanced stability protection of encapsulated biologics
  • Multivalent surface modification with targeted ligands
  • Controlled and sustained release profiles
  • Surface plasmon properties enable tracking and stimulus-triggered delivery
  • Ease of large-scale manufacturing

Through relentless research and application of cutting-edge methods, CD Formulation is driven to develop more ingenious solutions empowering global healthcare. Whether exploring novel targets or scaling established formulations, collaborating with our gold engineering experts can streamline progress. Interested in how working together might benefit your peptide, protein or other biologic objectives? Contact us and let's set up an exploratory consultation.

Reference

  1. Zhang X.; et al. The antitumor activity of Bax BH3 peptide delivered by gold nanoparticles. Frontiers in Materials, 2023, 9: 1099997.
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