Non-Cationic Polymer-Based Nanocarrier Development

With robust capabilities in material engineering, polymer synthesis and surface modification, CD Formulation is dedicated to designing and optimizing nanocarriers to encapsulate a wide range of biologics. Whether you need biodegradable nanoparticles, micelles, or hydrogels, we have the capabilities to engineer polymer-based platforms optimized for your projects.

Applications of Non-Cationic Polymers in Nucleic Acid Delivery

Non-cationic polymers have emerged as promising tools in nucleic acid delivery. These polymers offer advantages such as biocompatibility, controlled release, and stability. They can form self-assembled nanoparticles or encapsulate nucleic acids, protecting them from degradation and facilitating their cellular uptake. Moreover, their tunable properties allow for customization of particle size, surface charge, and degradation kinetics, enabling precise control over the delivery process.

Types of PLGA-lipids hybrid formulations (Ghitman J.; et al. 2020)

What Can We Do for Non-Cationic Polymer-Based Nanocarrier Development?

• PEG-Based Nanocarrier Development

PEG (polyethylene glycol) imparts stealth properties, reducing recognition by the immune system and extending circulation time. At CD Formulation, we can develop PEG-based nanocarriers through advanced formulation techniques, allowing precise control over particle size, surface functionality, and drug encapsulation.

• PLA-Based Nanocarrier Development

Through material selection and microfluidic techniques, our scientists fabricate PLA nanoparticles, micelles and hydrogels optimized for protective nucleic acid delivery. Modifications to molecular weight and properties can control carrier degradation and pharmacological parameters.

• PLGA-Based Nanocarrier Development

We have extensive experience engineering PLGA-based nanocarriers for nucleic acid delivery. As a biodegradable co-polymer, PLGA decomposes into non-toxic lactic and glycolic acids. CD Formulation can produce PLGA nanoparticles, microparticles and films tailored to controlled release kinetics and enhanced stability for targeted therapeutic applications.

• PCL-Based Nanocarrier Development

We recognize the opportunities in PCL-based nanocarrier development for controlled nucleic acid delivery. As a biocompatible and hydrophobic polyester, PCL degrades slowly over months and maintains its integrity well. Leveraging our formulation experience, we engineer PCL into customized platforms like nanoparticles, fibers and porous scaffolds.

Our Platforms for Polymer Nanocarrier Development

Highlights of Our Non-Cationic Polymer-Based Nanocarrier Development Services

• Our non-cationic nanocarriers, based on polymers like PEG, PLA, PLGA, and PCL, ensure improved biocompatibility, reducing potential toxicity and adverse effects.
• We specialize in formulating non-cationic nanocarriers with precise control over drug release kinetics, enabling sustained and targeted delivery of nucleic acids.
• We are skilled at the development of nanoparticles, micelles, hydrogels and many other types of nanocarriers.
• Our services provide tailored formulations, allowing customization of particle size, surface functionality, and encapsulation efficiency to meet specific requirements.
• We employ advanced characterization techniques to assess the physicochemical properties, stability, and performance of non-cationic nanocarriers, ensuring quality and reproducibility.

CD Formulation is a leading developer of advanced non-cationic polymer-based nanocarriers for nucleic acid therapeutics. Whether you require assistance with hit selection, structural optimization, scale up, or complete program management, we deliver integrated services to meet your nucleic acid delivery needs. Contact our scientific experts today to discuss leveraging our versatile nanocarrier development capabilities!