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Nanosphere Development for Peptide & Protein Delivery

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At CD Formulation, we leverage the latest nanotechnology innovations to enhance drug delivery for our partners in the biopharmaceutical industry. As leaders in nanomedicine, our nanosphere development center is dedicated to designing versatile particulate systems tailored to the unique properties of peptide and protein therapeutics.

Applications of Nanospheres in Drug Delivery

Nanospheres have numerous applications in the field of drug delivery due to their tunable properties and small size. Their stability allows for the controlled release of encapsulated drugs over extended periods. Nanospheres can co-deliver multiple drugs and imaging agents for combination and personalized therapies. They protect drugs from degradation and clearance in vivo, improving their pharmacokinetics. Overall, nanospheres provide an innovative solution for enhancing drug formulations with applications such as cancer treatment and gene delivery.

How Do We Develop Nanospheres for Peptide and Protein Delivery?

Process of Peptide Nanosphere Development – CD Formulation

Throughout the entire process, close collaboration between the development team and clients is crucial to ensure that the nanospheres meet the specific requirements and goals of the peptide and protein delivery project. At CD Formulation, our iterative process of design, optimization, characterization, and evaluation enables the development of nanospheres that can effectively deliver peptides and proteins, improving therapeutic outcomes in various applications.

  • Formulation Design

Based on the properties of the active ingredients, we carefully selected biocompatible and biodegradable materials as the building blocks of the nanospheres.

  • Encapsulation

We encapsulate peptides and proteins within nanospheres using techniques such as solvent evaporation, emulsion technology or nanoprecipitation.

  • Optimization

By optimizing formulation parameters, including polymer concentration, solvent system and manufacturing technology, we can control the size, surface properties and drug loading capacity of nanospheres to meet customer needs.

  • Functional Modification

We can functionally modify nanospheres with targeting ligands to promote specific recognition and binding to target cells or tissues and improve therapeutic effects.

  • Activity Evaluation

Once the nanospheres are developed, we can conduct a comprehensive activity assessment, including parameters such as release kinetics, cellular uptake, biodistribution, and therapeutic outcome.

Our Nanosphere Characterization Services

  • Size and morphology analysis by dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), and scanning electron microscopy (SEM).
  • Surface chemistry evaluation by Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS).
  • Thermal analysis using differential scanning calorimetry (DSC).
  • Drug loading and release kinetics quantification by high-performance liquid chromatography (HPLC) and fluorescence spectroscopy.
  • Immunogenicity studies, cytotoxicity assays, and permeation studies in cellular models.
  • Complete physicochemical analysis to guide each stage of formulation development.

Advantages of Our Nanosphere Development Services for Peptide & Protein Delivery

  • Our nanosphere formulations protect peptides and proteins from degradation, improving stability throughout circulation in the body.
  • Functionalized nanosphere surfaces enhance accumulation and uptake in desired cell and tissue types through ligand-mediated targeting.
  • Nanoscale size enables transport through biological barriers and improved distribution to extravascular sites ineffective for large molecule therapeutics.
  • Strategic surface PEGylation or polymer selection limits interactions with immune surveillance, lowering the risk of neutralizing antibody development.
  • Our full-service model provides formulation, process, and analytical support to expedite candidate progression to market.

CD Formulation is a leader in the development of targeted nanosphere delivery systems for peptides and proteins. We utilize our expertise and analytical technologies to create customized nanosphere formulations. Our scientists have extensive experience utilizing diverse materials and surface modifications to generate controlled release nanocarriers. Whether you require encapsulation, surface functionalization or pharmacokinetic testing, our full-service development helps advance your biologic to the market through optimized delivery. If you need our services, please contact us!

Reference

  1. Díez N.; et al. Dense (non-hollow) carbon nanospheres: synthesis and electrochemical energy applications. Materials Today Nano. 2021, 16: 100147.
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